Table 1.

Clinical criteria and levels of evidence for evaluation of patients with suspected drug-induced thrombocytopenia.

Clinical criteria

(1) Drug administration preceded thrombocytopenia; complete and sustained recovery from thrombocytopenia is noted after drug discontinuation

(2) Other drugs administered prior to thrombocytopenia were continued or reintroduced after discontinuation of the suspected drug

(3) Other etiologies of thrombocytopenia excluded

(4) Reexposure to the drug resulted in recurrent thrombocytopenia

Levels of evidence

(1) Definite: all 4 criteria met

(2) Probable: criteria 1–3 met

(3) Possible: criterion 1 met

(4) Unlikely: criterion 1 not met

Adapted from http://www.ouhsc.edu/platelets and Reference [6].