Table 2.
Immunohistochemical findings in malignant peripheral nerve sheath tumors
| Marker |
Core Mean ± SD (range) |
Periphery Mean ± SD (range) |
w | P‐value |
|---|---|---|---|---|
| Total | ||||
| MCD (%) | 2.19 ± 2.03 (0.19‐8.96) | 2.67 ± 3.62 (0.27‐15.27) | 5.75 | 0.97 |
| MVD (vessels/mµ2) | 175.6 ± 62.97 (75.05‐346.7) | 197.6 ± 58.39 (104.8‐352.3) | 365.5 | 0.07 |
| Ki‐67 (%) | 7.65 ± 11.96 (0.08‐48.94) | 5.84 ± 8.33 (0.04‐44.09) | 540.5 | 0.7 |
| NF1 | ||||
| MCD (%) | 2.07 ± 1.7 (0.2‐5.13) | 2.11 ± 1.46 (0.27‐5.77) | 132.5 | 0.68 |
| MVD (vessels/mµ2) | 198.1 ± 67.68 (106.6‐346.7) | 215.1 ± 69.45 (104.8‐352.3) | 108.5 | 0.47 |
| Ki‐67 (%) | 7.87 ± 12.35 (0.27‐48.94) | 6.78 ± 11.14 (0.47‐44.09) | 140 | 0.45 |
| Sporadic | ||||
| MCD (%) | 2.31 ± 2.37 (0.19‐8.96) | 3.23 ± 4.92 (0.29‐15.27) | 154 | 0.76 |
| MVD (vessels/mµ2) | 151.6 ± 48.86 (75.05‐284.3) | 180 ± 39.72 (135.3‐309.3) | 67 | 0.037 |
| Ki‐67 (%) | 7.43 ± 11.95 (0.08‐48.06) | 5.03 ± 4.93 (0.04‐15.45) | 133.5 | 0.93 |
| NF1 (mean) | Sporadic (mean) | NF1 (mean) | Sporadic (mean) | |||
|---|---|---|---|---|---|---|
| MCD (%) | 2.07 ± 1.7 | 2.31 ± 2.37 | — | — | 149 | 0.89 |
| MVD (vessels/mµ2) | 198.1 ± 67.68 | 151.6 ± 48.86 | — | — | 190 | 0.053 |
| Ki‐67 (%) | 7.87 ± 12.35 | 7.43 ± 11.95 | — | — | 134 | 0.84 |
| MCD (%) | — | — | 2.11 ± 1.46 | 3.23 ± 4.92 | 180 | 0.22 |
| MVD (vessels/mµ2) | — | — | 215.1 ± 69.45 | 180 ± 39.72 | 149 | 0.14 |
| Ki‐67 (%) | — | — | 6.78 ± 11.14 | 5.03 ± 4.93 | 116 | 0.68 |
MCD, mast cell density; MVD, microvascular density; NF1, neurofibromatosis type 1.
Bold value emphasize statistical significance.