Table 4.
Univariate analysis of predictors of overall survival
| Variable | Overall survival (median, mo) | HR (95% CI) | P‐value |
|---|---|---|---|
| NF1 status | |||
| No (sporadic) | 57 | Ref | |
| Yes | 14 | 2.44 (1.06‐5.60) | 0.036 |
| Tumor size | |||
| <10 cm | 60 | Ref | |
| >10 cm | 16 | 3.24 (1.18‐8.88) | 0.023 |
| MCD core (%) | |||
| Lower tercile | 15 | Ref | |
| Interm. tercile | 28 | 1.07 (0.40‐2.86) | 0.893 |
| Upper tercile | 57 | 0.66 (0.22‐1.98) | 0.458 |
| MCD periphery (%) | |||
| Lower tercile | 30 | Ref | |
| Interm. tercile | 15 | 2.54 (0.95‐6.75) | 0.062 |
| Upper tercile | 60 | 0.58 (0.19‐1.80) | 0.350 |
| MVD core (vessels/mµ2) | |||
| Lower tercile | 60 | Ref | |
| Interm. tercile | 36 | 1.77 (0.60‐5.20) | 0.301 |
| Upper tercile | 10 | 2.20 (0.75‐6.42) | 0.151 |
| MVD periphery (vessels/mµ2) | |||
| Lower tercile | 72 | Ref | |
| Interm. tercile | 36 | 2.11 (0.57‐7.81) | 0.265 |
| Upper tercile | 13 | 8.22 (2.19‐30.81) | 0.002 |
| Ki‐67 core (%) | |||
| Lower tercile | 18 | Ref | |
| Interm. tercile | 21.5 | 1.01 (0.33‐3.11) | 0.983 |
| Upper tercile | 51 | 0.83 (0.31‐2.23) | 0.710 |
| Ki‐67 periphery (%) | |||
| Lower tercile | 29 | Ref | |
| Interm. tercile | 57 | 1.40 (0.45‐4.39) | 0.562 |
| Upper tercile | 60 | 2.26 (0.78‐6.56) | 0.133 |
HR, hazard ratio; Interm., intermediate; MCD, mast cell density; MVD, microvascular density; NF1, neurofibromatosis type 1; ref, reference.