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. 2019 Feb 10;8(3):1232–1245. doi: 10.1002/cam4.1992

Figure 4.

Figure 4

The effect of Nr5a2 inhibition on tumorigenicity and progression in C57BL/6 mice with left lung orthotopic implantation. (A) A schematic overview of orthotopic implantation of LLC‐SD cell lines in C57BL/6 mice. (B) Images of left lung orthotopic nodules in C57BL/6 mice injected with LLC‐SD‐shNr5a2 or control cells (n = 7). (C) Immunohistochemistry analysis of orthotopic tumors derived from LLC‐SD‐shNr5a2 and control cells transplanted to the lung of C57BL/6 mice. Scale bars = 120 μm, the black box indicates the enlarged area, bar = 60 μm. (D) In vivo survival assay (Materials and methods)