Figure 5. Silencing of Apc contributed to up-regulation of the protein expression of NF-κB p65, MMP-2, MMP-9, TNF-α, and IL-1β, and down-regulation of Apc and IκBα according to detection by Western blot analysis.

(A) Protein bands of NF-κB p65, MMP-2, MMP-9, TNF-α, IL-1β, IL-6, Apc, and IκBα as well as extent of p65 phosphorylation in rats in each group. (B) Quantitative analysis of protein expression of NF-κB p65, MMP-2, MMP-9, TNF-α, IL-1β, IL-6, Apc, and IκBα, as well as the extent of p65 phosphorylation of rats in each group; *P<0.05 compared with the normal group; ^#P<0.05 compared with the blank and NC groups.