Table 5. ELISA detection demonstrates that Apc-siRNA increases levels of MCP-1, TNF-α, IL-1β, and IL-6 in brain tissue homogenate of rat models with IA.
| Group | n | MCP-1 (pg/ml) | TNF-α (ng/ml) | IL-1β (ng/l) | IL-6 (pg/ml) |
|---|---|---|---|---|---|
| Normal | 10 | 54.28 ± 9.23 | 1.27 ± 0.36 | 69.38 ± 7.21 | 91.68 ± 16.28 |
| Blank | 10 | 78.49 ± 10.23* | 2.54 ± 0.49* | 89.26 ± 12.47* | 128.67 ± 19.08* |
| NC | 10 | 87.76 ± 11.34* | 2.58 ± 0.58* | 96.48 ± 13.42* | 142.51 ± 20.48* |
| Apc-siRNA-1 | 10 | 109.27 ± 16.59*† | 4.31 ± 1.62*† | 118.53 ± 17.84*† | 182.94 ± 23.92*† |
| Apc-siRNA-3 | 10 | 112.27 ± 15.54*† | 4.67 ± 1.24*† | 120.11 ± 12.49*† | 186.94 ± 27.33*† |
*P<0.05 compared with the normal group.
#All P<0.05 compared with the blank and NC groups.