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. 2019 Mar 22;21(4):401–412. doi: 10.1016/j.neo.2019.02.003

Figure 3.

Figure 3

HCEC+7 results in genome-wide structural changes. (A) A change in chromatin partitioning is observed in chromosome 14. The left and right side show HCEC and HCEC+7, respectively. The top row shows the average gene expression for each 100 kb bin. The middle row shows the Fiedler vector partitioning. A clear change is observed between 425 and 450 (blue square). The bottom row is the Hi-C contact map for chromosome 14, shown at 100 kb resolution, log-scale. (B) HCEC+7 shows a clear change in chromosome 4 patterning. The left and right side show HCEC and HCEC+7, respectively. The top row shows the Fiedler vector partitioning. The middle row is the Hi-C contact map for chromosome 4, shown at 100 kb resolution, log-scale. Squares (green and blue) along the diagonal of the Hi-C matrix depict the TAD structure. A direct comparison of the TAD structure between samples is shown below.