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Fit of a three-compartment metabolic model to 13C turnover of hippocampal amino acids in (I) glutamate, (II) GABA, and (III) glutamine/aspartate. [1,6-13C2]Glucose was administered in mice for pre-defined time. 13C concentrations of amino acids were measured in hippocampal extracts in 1H-[13C]-NMR spectra. Symbols depict to the measured labeling, while lines represent the best fit of the metabolic model to the measured values.
