Table 1.

Non-displaceable BP_NDs from the two PET scans, and % change in BP_ND0 and BP_ND1, as calculated by equation (2).

Volumes of interest	BPND0 (mean ± SD)	BPND1 (mean ± SD)	ΔBPND (%) (mean ± SD)	BPND 0/1	BPND 0/0
Saline (n = 10)				ICC
Cortex (total)	0.66 ± 0.10	0.66 ± 0.13	−1 ± 5	0.98	0.94
Frontal	0.57 ± 0.11	0.54 ± 0.13	−5 ± 7	0.97	0.92
Somatosensory	0.60 ± 0.10	0.58 ± 0.14	−4 ± 8	0.96	0.95
Occipital	0.78 ± 0.11	0.74 ± 0.12	−5 ± 3	0.97	0.84
Insula	0.73 ± 0.10	0.76 ± 0.14	5 ± 8	0.91	0.87
Temporal	0.71 ± 0.12	0.72 ± 0.14	1 ± 6	0.97	0.95
Thalamus	0.90 ± 0.14	0.95 ± 0.22	4 ± 10	0.90	0.92
Dorsal striatrum	1.49 ± 0.20	1.59 ± 0.20	7 ± 5	0.85	0.80
Escitalopram (n = 5)				Required sample size
Cortex (total)	0.71 ± 0.10	0.68 ± 0.12	−4 ± 8	11	19
Frontal	0.64 ± 0.12	0.60 ± 0.13	−6 ± 12	8	16
Somatosensory	0.65 ± 0.11	0.60 ± 0.13	−8 ± 9	8	9
Occipital	0.79 ± 0.11	0.73 ± 0.10	−7 ± 6	5	11
Insula	0.81 ± 0.09	0.83 ± 0.15	2 ± 9	126	149
Temporal	0.76 ± 0.10	0.72 ± 0.12	−5 ± 7	8	11
Thalamus	0.98 ± 0.11	1.03 ± 0.23	4 ± 13	67	63
Dorsal striatrum	1.64 ± 0.23	1.76 ± 0.30	8 ± 12	17	21
Fenfluramine (n = 5)
Cortex (total)	0.64 ± 0.09	0.56 ± 0.12	−13 ± 8	5	6
Frontal	0.56 ± 0.11	0.47 ± 0.14	−18 ± 10	5	6
Somatosensory	0.58 ± 0.11	0.50 ± 0.14	−15 ± 10	6	6
Occipital	0.73 ± 0.07	0.61 ± 0.11	−16 ± 8	4	5
Insula	0.70 ± 0.11	0.64 ± 0.12	−8 ± 9	8	11
Temporal	0.66 ± 0.11	0.57 ± 0.15	−13 ± 8	5	6
Thalamus	0.95 ± 0.20	0.89 ± 0.22	−7 ± 8	24	20
Dorsal striatrum	1.51 ± 0.12	1.48 ± 0.19	−2 ± 6	110	131

Note: The intercorrelation coefficient (ICC) is given for both within-PET scan (BP_ND 0/1) and between-PET scans (BP_ND 0/0) along with the required sample size given a power of 0.8, significance level of 0.05 and the effect size determined by the mean BP_ND ± SD and the ICC.