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. 2018 Jul 12;27(8):1185–1194. doi: 10.1177/0963689718756070

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 7. — Proposed mechanism of osteopontin (OPN) stimulated monocyte chemoattractant protein 1 (MCP-1) production and migration of monocytes. OPN could directly stimulate MCP-1 production and migration of monocytes through the activation of integrin β1-c-Jun NH2-terminal kinase/p38 pathway, then lead to the recruitment of inflammatory cells and the formation of the inflammatory microenvironment. This has been highlighted as an important factor responsible for the sensitivity of inflammatory diseases to therapies and prognosis of patients.