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. 2018 Mar 22;27(1):23–30. doi: 10.1177/0963689717727541

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 4. — (A and B) Histochemical detection of DPP-IV (CD26) positive donor-derived clusters into the liver of recipient animals. (A) Cluster of engrafted rAECs after differentiating into hepatocytes: the expression pattern of CD26 in rAEC-derived cells is polarized and localized at the bile canaliculi between 2 hepatocytes (see inset). (B) rAEC-derived clusters with morphology of hepatic sinusoidal endothelial cells: cells were engrafted in between resident hepatocytes and CD26 expression was homogeneously distributed in the cytoplasm (see inset). (C–H) Double immunofluorescence staining for CD26 and endothelial markers RECA-1 and SE-1 performed on serial liver tissue sections. In all the observed clusters, CD26 positive cells also expressed RECA-1 and SE-1. (C–E) RECA-1 + CD26 staining; (F–H) SE-1 + CD26 staining. 200× Magnification. Insets show 600× magnification.