Table 2.
Linear mendelian randomisation estimates. Hazard ratios for all cause mortality for each 1 unit increase in body mass index (BMI)
| All cause mortality | HUNT Study | UK Biobank | Overall | |||||
|---|---|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |||
| Overall | 1.03 (1.00 to 1.06) | 0.09 | 1.05 (1.02 to 1.09) | 0.002 | 1.04 (1.02 to 1.06) | <0.001 | ||
| Men | 1.01 (0.96 to 1.06) | 0.75 | 1.05 (1.01 to 1.10) | 0.03 | 1.04 (1.00 to 1.07) | 0.05 | ||
| Women | 1.05 (1.00 to 1.09) | 0.03 | 1.06 (1.01 to 1.11) | 0.03 | 1.05 (1.02 to 1.09) | 0.002 | ||
| Within residual BMI categories: | ||||||||
| Underweight (<18.5) | 0.79 (0.56 to 1.13) | 0.19 | 0.57 (0.41 to 0.79) | <0.001 | 0.66 (0.52 to 0.84) | <0.001 | ||
| Low normal weight (18.5-19.9) | 0.90 (0.71 to 1.14) | 0.40 | 0.82 (0.66 to 1.03) | 0.09 | 0.86 (0.73 to 1.01) | 0.07 | ||
| High normal weight (20.0-24.9) | 0.98 (0.93 to 1.04) | 0.61 | 1.00 (0.94 to 1.06) | 0.98 | 0.99 (0.95 to 1.04) | 0.07 | ||
| Overweight (25.0-29.9) | 1.04 (0.99 to 1.09) | 0.10 | 1.05 (1.00 to 1.11) | 0.04 | 1.05 (1.01 to 1.08) | 0.01 | ||
| Obese (≥30.0) | 1.05 (0.98 to 1.13) | 0.14 | 1.11 (1.05 to 1.18) | <0.001 | 1.09 (1.04 to 1.14) | <0.001 | ||
| Trend test | NA | 0.05 | NA | 0.02 | NA | 0.01 | ||
NA=not applicable.