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. 2019 Mar 26;2019(3):CD009261. doi: 10.1002/14651858.CD009261.pub4

DiMuzio 2017.

Methods Study design: randomised controlled trial
 Study grouping: parallel
Ethics and informed consent: not provided
Follow‐up period: 30 days
Sample size calculation: not stated
ITT analysis: number randomised: 120 number analysed: 120
Funding: not stated
Pre‐registration: not stated
Participants Location: Philadelphia, USA
 Intervention group (high risk): n = 59control group (high risk): n = 60 (3 arms: low risk: n = 21)
Mean age: not provided
 Inclusion criteria: femoral incisions closed primarily following elective vascular surgery
 Exclusion criteria: none stated
Interventions Aim/s: to prospectively evaluate negative pressure therapy as a means to decrease wound complications and associated healthcare costs
Group 1 (NPWT) intervention: NPWT
Group 2 (control) intervention: standard gauze dressing
 Study date/s: not provided
Outcomes
  • infection

  • LOS

  • reoperation

  • readmission


Validity of measure/s: not provided
Time points: over 30 days
Notes Conference abstract
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not reported
Allocation concealment (selection bias) Unclear risk Not reported
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Evidence for participants: not possible
Comment: unlikely to affect outcomes
Evidence for personnel: not possible
Comment: unlikely to affect outcomes
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Not reported
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 140 (3 arms) were enrolled and analysed.
Selective reporting (reporting bias) Low risk Planned outcomes reported.
Other bias Unclear risk No other biases detected.