FIG. 2.

ddPCR and p24 pattern throughout the MWRI-01 study. Each symbol represents the cumulative mean ± SE at each study visit (n = 24; 6 patients each with 4 biopsy replicates). Day 0 (baseline, before rilpivirine injection), 28, 56, 84, and 112 after rilpivirine for p24 and each ddPCR method are displayed. Cumulative values were calculated by taking the sum of days 3 through 14 of explant culture, biopsy weight adjusted, and log transformed. Units: Log₁₀[(pg/mL)/mg] for p24 and Log₁₀ [(copies/mL)/mg] for all ddPCR methods. Repeated measures ANOVA test with the mean of day 0 set as the control was performed for each method with significance set to 0.05. **p ≤ .005, ***p ≤ .001, ****p ≤ .0001. Each significance annotation between study visits applies to all four methods.