FIG. 4.

SHBG is a novel target of hypothermia with unknown function(s) postcooling in humans and in bears. Illustration shows protein targets that are similarly altered (increased or decreased) by cooling in juvenile hibernating bears (Welinder et al., 2016) versus adult human CA patients treated with TH and who had a good neurological outcome (Deng et al., 2018). In both studies, proteomic changes were detected by mass spectrometry of blood plasma, and SHBG levels were among the highest fold change (compared with respective controls) among the identified proteins. CA, cardiac arrest; SHBG, sex hormone binding globulin.