FIG. 6.

Medical conditions amenable to a “Hypothermia in a Syringe” strategy. Hypothermia in a Syringe is the theoretical concept that CSH/CSP levels can be (collectively) pharmacologically manipulated in normothermic or hypothermic patients to mimic (or augment) aspects of beneficial cold response physiology and cell signaling cascades. The illustration shows examples of major research fields (individual fruits), and medical conditions relevant to each (white text), which may represent low-hanging fruit for clinical translation. Prioritization of the “lowest hanging fruit” is left to the reader to interpret given that the metaphor is context dependent (e.g., the lowest hanging fruit might represent a condition most applicable to a therapy, or alternatively a condition via which a therapy is able to translate into the clinic the fastest).