Table 3.

Tests for significance of differences across the study period in MDRO infection incidence density (MDRO), hand hygiene compliance, and alcohol-based hand rub usage (AHRU), respectively, within and across trial arms (hand hygiene compliance data are from [15] and reprinted with permission)

	ASH-trial arm			Tailoring-trial arm			Comparison of trial arms
a) MDRO	Difference	95%-CI	p-value	Difference	95%-CI	p-value	F	p-value
2014 vs. 2013	-0.086 i. per 1 k inpatient days	[-0.629; 0.456]	p = 0.730	-0.260 i. per 1 k inpatient days	[-0.803; 0.282]	p = 0.310	0.255	p = 0.625
2015 vs. 2014	0.064 i. per 1 k inpatient days	[-0.355; 0.483]	p = 0.739	-0.237 i. per 1 k inpatient days	[-0.656; 0.182]	p = 0.236	1.285	p = 0.283
2015 vs. 2013	-0.022 i. per 1 k inpatient days	[-0.400; 0.356]	p = 0.899	-0.497 i. per 1 k inpatient days	[-0.857; -0.119]	p = 0.015	3.927	p = 0.076
b) Hand hygiene compliance	Difference	95%-CI	p-value	Difference	95%-CI	p-value	Chi 2	p-value
2014 vs. 2013	+13%	[9.8; 16.1]	p < 0.001	+10%	[6.3; 12.6]	p < 0.001	2.3	p = 0.126
2015 vs. 2014	-4%	[-7.7; -1.2]	p = 0.007	+6%	[2.5; 9.3]	p = 0.001	18.5	p < 0.001
2015 vs. 2013	+9%	[5.1; 11.8]	p < 0.001	+16%	[11.9; 18.9]	p < 0.001	7.9	p = 0.005
c) AHRU	Difference	95%-CI	p-value	Difference	95%-CI	p-value	F	p-value
2014 vs. 2013	+20 ml per inpatient day	[-12.2; 51.4]	p = 0.199	+3 ml per inpatient day	[-29.7; 34.0]	p = 0.883	0.8	p = 0.407
2015 vs. 2014	+6 ml per inpatient day	[-10.2; 23.7]	p = 0.397	-2 ml per inpatient day	[-18.7; 15.2]	p = 0.827	0.6	p = 0.452
2015 vs. 2013	+26 ml per inpatient day	[-1.1; 53.8]	p = 0.058	+1 ml per inpatient day	[-27.0; 27.9]	p = 0.972	2.2	p = 0.168