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. Author manuscript; available in PMC: 2019 Mar 26.
Published in final edited form as: ACS Chem Biol. 2016 Nov 29;12(1):36–40. doi: 10.1021/acschembio.6b00977

Figure 3.

Figure 3.

Serum pharmacokinetic results for vaccinated and unvaccinated mice (n=6 overall, n=2 per time point) following intraperitoneal cassette injection of 4 mg/kg oxycodone (A) and hydrocodone (B). Dotted lines represent the 95% CI for each regression. Biodistribution of oxycodone and hydrocodone in blood and brain samples. Vaccinated and naive mice (n=3) were intraperitoneally dosed with oxycodone at 4 mg/kg (C) or hydrocodone at 8 mg/kg (D), then trunk blood and brain were harvested 15 min post-injection. Survival rates following administration of lethal doses of prescription opioids. Vaccinated and unvaccinated animals (n=7–8) were dosed SC with 426 mg/kg of oxycodone (E) or 86 mg/kg of hydrocodone (F), and survival was measured continuously for 120 min, then again at 12 and 24 hours post injection. Bars denote means ± SEM. *=p < 0.01; ***=p < 0.0001 one way ANOVA.