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. Author manuscript; available in PMC: 2019 Mar 26.
Published in final edited form as: Annu Rev Physiol. 2017 Oct 13;80:49–70. doi: 10.1146/annurev-physiol-022516-034008

Figure 1.

Figure 1

Overview of the synthesis and actions of leukotrienes. Ca2+-activated 5-LO translocates to either the inner or outer nuclear membrane and converts arachidonic acid to LTA4 under the influence of FLAP. LTA4 is further metabolized to LTB4 or LTC4. These are transported out of the cell by MRP4 or MRP1. LTC4 can be sequentially metabolized into LTD4 and LTE4. The molecules bind to BLT or CysLT receptors and elicit biological or pathological functions. Abbreviations: 5-LO, 5-lipoxygenase; BLT, LTB4 receptor; cPLA2, cytosolic phospholipase A2; CysLT, cysteinyl LT receptor; FLAP, 5-LO-activating protein; LT, leukotriene; LTA4H, LTA4 hydrolase; LTB4, leukotriene B4; LTC4S, LTC4 synthase; MRP, multidrug resistance-associated protein; Th17, T helper 17.