Table 1.

Comparative efficacies of immunological and molecular markers in diagnosis of leprosy

Name of the test	Types of leprosy		Sensitivity/Specificity (%)
	PB patients	MB patients
	Percent (%) positivity
Serological marker (PGL-1)	0-40%[10,11,12,27]	70-95%[10,11,12,27]	91%[27]
Evaluation of dipstick assay using ND-O-BSA-based ELISA	-	-	94.9% concordance with ELISA[24]
ML-flow test	40%[27,28]	97.4%[27,28]	97.4%/90.2%[27,28]
35-kD-based serology	46.7%[39]	98.5%[39]	98.4%/100%[40] 90%/97.5%[42]
NDO-LID rapid test	15.4-21.2%[58]	83.3-87%[58]	87%/96.1%[58]
PCR using gene targetRLEP	73%[67] 83%[70]	100%[67,68] 96.6%[71]	73.6%/100%[67] 87.1%[72]
PCR using 16SrRNA gene target	50%[71]	100%[71]	51%/100%[70]
PCR using Ag85B gene target	80%9[72]	100%[72]	56%/100%[70]
PCR using 18kDa gene target	74%[73]	99%[73]	100%/83%[73]
Proline-rich antigen (pra-36 kDa)	36-60%[75,76,77]	87-100%[75,76,77]	-
Multiplex PCR	83%[68]	100%[68]	-

^#Reference numbers have been super fixed against the values