Table 2.
Logistic regression analysis for the risk of hyperkalemia according to etiology of CKD
| CKD subcohort | Unadjusted | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| PKD | (Reference) | (Reference) | (Reference) | (Reference) | ||||
| DN | 9.52 (6.02–15.06) | < 0.001 | 8.77 (4.74–16.24) | < 0.001 | 4.65 (2.42–8.93) | < 0.001 | 4.91 (2.54–9.50) | < 0.001 |
| HTN | 3.42 (2.10–5.57) | < 0.001 | 3.47 (2.07–5.83) | < 0.001 | 2.54 (1.50–4.30) | 0.001 | 2.57 (1.51–4.37) | < 0.001 |
| GN | 2.79 (1.76–4.42) | < 0.001 | 2.92 (1.82–4.66) | < 0.001 | 1.70 (1.03–2.81) | 0.038 | 1.82 (1.10–3.03) | 0.02 |
| Unclassified | 4.57 (2.55–8.17) | < 0.001 | 4.59 (2.44–8.65) | < 0.001 | 2.86 (1.48–5.53) | 0.002 | 2.95 (1.52–5.72) | 0.001 |
Model 1: adjusted age, sex, history of DM, BMI, and SBP
Model 2: Model 1 + serum sodium and UPCR*
Model 3: Model 2 + use of RAAS blockade, diuretics, CCB, and beta blockers
*Data were log transformed
Abbreviations: CKD Chronic kidney disease, OR odds ratio, CI Confidence interval, PKD Polycystic kidney disease, DN Diabetic nephropathy, HTN Hypertensive nephrosclerosis, GN, glomerulonephritis; eGFR, estimated glomerular filtration rate; BMI Body mass index; SBP, systolic blood pressure; UPCR, urine protein-to-creatinine ratio; RAAS, renin-angiotensin-aldosterone system; CCB, calcium channel blocker