Table 2.
Prognostic performance of different gene signature panels related to LGG.
| TCGA | CGGA | ||||
|---|---|---|---|---|---|
| (515 patients) | (170 patients) | ||||
| Gene signatures | Numer of genes | k | Cox p-value | k | Cox p-value |
| Proposed signature | 20 | 4 | 5.48E-09 | 5 | 1.82E-04 |
| Olar et al. | 6 | 5 | 6.97E-02 | 5 | 5.43E-03 |
| Wang et al. | 20 | 2 | 1.42E-01 | 4 | 8.07E-01 |
| Liu et al. | 18 | 5 | 3.21E-06 | 2 | 1.12E-02 |
Clustering is performed by using PINS. The number of clusters identified by the algorithm is denoted by k. The cells highlighted in yellow represent the Cox p-values that are significant (< 0.01). The cells highlighted in green represent the best signature (i.e., lowest Cox p-value) for each dataset. These results indicate that the proposed signature is able to achieve the lowest Cox p-values on both independent datasets.