Table 2.
The prognostic factors of the 38 elderly patients with cryptococcal meningitis
| Survivors (n = 24) | Non-survivors (n = 14) | p-value | |
|---|---|---|---|
| Gender | |||
| Male | 11 | 5 | |
| Female | 13 | 9 | 0.542 |
| Underlying disease | |||
| AIDS | 0 | 1 | 0.368 |
| Diabetes mellitus | 9 | 6 | 0.744 |
| Liver cirrhosis | 1 | 2 | 0.542 |
| Hematologic disorders | 4 | 1 | 0.633 |
| Autoimmune disorders | 1 | 2 | 0.542 |
| Malignancy | 3 | 3 | 0.650 |
| Chronic obstructive pulmonary disease | 1 | 4 | 0.052 |
| Adrenal insufficiency | 3 | 4 | 0.387 |
| Immunocompromised state | 7 | 10 | 0.011 |
| Initial presentation | |||
| Headache | 11 | 6 | 0.859 |
| Altered consciousness | 17 | 12 | 0.438 |
| Fever | 11 | 10 | 0.126 |
| Seizure | 4 | 2 | 1.000 |
| Visual disturbance | 1 | 0 | 1.000 |
| Hearing impairment | 0 | 1 | 0.368 |
| Cerebrospinal fluid data | |||
| White blood cell count (109/L) | 0.09 | 0.09 | 0.950 |
| Glucose (mmol/L) | 2.77 | 3.21 | 0.664 |
| Protein (g/L) | 2.65 | 2.32 | 0.835 |
| Lactate (mmol/L) | 5.36 | 5.34 | 0.982 |
| Positive India ink stain | 3 | 6 | 0.050 |
| Cryptococcal Ag titer (≥1024) | 5 | 7 | 0.071 |
| Positive culture result | 16 | 10 | 0.711 |
| Serum cryptococcal antigen titer (≥1024) | 5 | 7 | 0.130 |
| Cryptococcemia | 2 | 7 | 0.006 |
| Extraneural involvement | 3 | 2 | 1.000 |
| Image finding | |||
| Basal meningeal enhancement | 8 | 4 | 1.000 |
| Pseudocyst/VR space dilatation | 10 | 4 | 0.365 |
| Hydrocephalus | 9 | 6 | 0.823 |
| Recent cerebral infarction | 5 | 6 | 0.268 |
| Cryptococcoma | 1 | 0 | 1.000 |
AIDS acquired immunodeficiency syndrome, Ag antigen, VR Virchow-Robin