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. 2019 Mar 22;12:1069–1076. doi: 10.2147/JPR.S188619

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© 2019 Coffeen and Pellicer. This work is published and licensed by Dove Medical Press Limited

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The figure shows the analgesic effect of intraperitoneal injection of different doses of anandamide (AN, 3 and 30 mg/kg), Salvia divinorum extract (SD, 10 and 100 mg/kg), and its coadministration (SD + AN, 10 and 3 mg/kg, respectively) in the hot plate test in rats.

Notes: (A) Licking behavior: this behavior is presented between 2 and 4 seconds after the animal is put in the hot plate and is related to supraspinal nuclei activation. (B) Escape behavior: this behavior also involves supraspinal nuclei and is related to cognitive processes. Note that in both behavioral responses, the SD + AN administration induces a significant analgesic effect with respect to vehicle administration (VEH), similar to the high dose of SD, suggesting a synergistic effect (*ANOVA, P=0.05).