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. 2019 Mar 22;12:2137–2147. doi: 10.2147/OTT.S195655

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© 2019 Zhong et al. This work is published and licensed by Dove Medical Press Limited

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THZ1 inhibited gene transcription in cervical cancer.

Notes: (A) Western blot was used to assess the RNA Pol II protein and its phosphorylation at serine 2, serine 5, and serine 7 (S2, S5, and S7) in cervical cancer cells after treatment with the indicated concentrations of THZ1. (B) A heatmap revealed gene expression changes (log2-fold) after THZ1 (100 nM) treatment in HeLa cells for 6 hours compared to the negative control. (C) Gene ontology enrichment revealed the gene transcripts inhibited by THZ1 in HeLa. (D) qRT-PCR revealed the expression of c-MYC, hTERT, RAD51, and BCL-2 (*P<0.05, Student’s t-test). (E) qRT-PCR revealed the expression of HPV viral oncogenes E6 and E7 after THZ1 treatment (*P<0.05, Student’s t-test).

Abbreviation: HPV, human papillomavirus.

THZ1 inhibited gene transcription in cervical cancer.

Notes: (A) Western blot was used to assess the RNA Pol II protein and its phosphorylation at serine 2, serine 5, and serine 7 (S2, S5, and S7) in cervical cancer cells after treatment with the indicated concentrations of THZ1. (B) A heatmap revealed gene expression changes (log2-fold) after THZ1 (100 nM) treatment in HeLa cells for 6 hours compared to the negative control. (C) Gene ontology enrichment revealed the gene transcripts inhibited by THZ1 in HeLa. (D) qRT-PCR revealed the expression of c-MYC, hTERT, RAD51, and BCL-2 (*P<0.05, Student’s t-test). (E) qRT-PCR revealed the expression of HPV viral oncogenes E6 and E7 after THZ1 treatment (*P<0.05, Student’s t-test).

Abbreviation: HPV, human papillomavirus.