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. Author manuscript; available in PMC: 2019 Apr 23.
Published in final edited form as: Curr Biol. 2018 Apr 23;28(8):R421–R434. doi: 10.1016/j.cub.2018.03.010

Figure 4.

Figure 4

Models of compositional control for the ciliary membrane

A, The transition zone contains binding sites for select ciliary membrane proteins [52], and live imaging studies have shown that SMO pauses in the transition zone [78]. Thus, the transition zone may control the entry and exit of membrane-associated proteins from the cilium. B, The BBSome exports and imports ciliary membrane proteins such as GPCRs. C, A membrane diffusion barrier retains ciliary membrane proteins and excludes non-ciliary membrane proteins. D, Intraflagellar transport complexes enrich or deplete proteins in the cilium by coordinating with BBSome-facilitated trafficking across the transition zone.