. 2018 Dec 19;2(1):131–138. doi: 10.1093/jamiaopen/ooy050

Table 2.

Top 20 ranked new AD risk genes

Rank	Gene_symbol	Gene_name	Location	Type
1	UBC^a	Ubiquitin C	Cytoplasm	Enzyme
2	NOTCH1^a	Notch 1	Plasma Membrane	Transcription regulator
3	EGFR^a	Epidermal growth factor receptor	Plasma Membrane	Kinase
4	ALB	Albumin	Extracellular Space	Transporter
5	APLP2^a	Amyloid beta precursor like protein 2	Cytoplasm	Other
6	APLP1^a	Amyloid beta precursor like protein 1	Extracellular Space	Other
7	CP^a	Ceruloplasmin	Extracellular Space	Enzyme
8	PRDM10^a	PR/SET domain 10	Nucleus	Transcription regulator
9	APBA2^a	Amyloid beta precursor protein binding family A member 2	Cytoplasm	Transporter
10	NAE1^a	NEDD8 activating enzyme E1 subunit 1	Cytoplasm	Enzyme
11	NCSTN	Nicastrin	Plasma Membrane	Peptidase
12	SHC1^a	SHC adaptor protein 1	Cytoplasm	OTHER
13	KAT5^a	Lysine acetyltransferase 5	Nucleus	Transcription regulator
14	TSPO^a	Translocator protein	Cytoplasm	Transmembrane receptor
15	BACE1	Beta-secretase 1	Cytoplasm	Peptidase
16	APBA3^a	Amyloid beta precursor protein binding family A member 3	Cytoplasm	Transporter
17	BLMH	Bleomycin hydrolase	Cytoplasm	Peptidase
18	GEN1^a	GEN1, Holliday junction 5′ flap endonuclease	Cytoplasm	Enzyme
19	APBA1	Amyloid beta precursor protein binding family A member 1	Cytoplasm	Transporter
20	TP53	Tumor protein p53	Nucleus	Transcription regulator

New AD risk genes that are not included in AlzGene database.