Figure 2.

Serum E concentrations. Serum E was higher in the ImE group than the placebo group throughout the study. DE treatment caused an immediate increase in serum E concentrations, which were significantly higher than in the placebo-treated group but not different from the ImE group. Data are mean ± SEM. *Groups are different by two-way ANOVA. Except 4- and 6-month points, ImE and DE (during E treatment) were significantly different from the placebo group at all other points by Sidak post hoc pairwise comparison. Plac, placebo.