Table 1.

Longitudinal Body Composition and Serum Leptin Concentrations of Old OvH Female Monkeys on an Obesogenic Diet and Treated With Placebo, ImE, or Placebo for 24 Months Then DE

	Total Weight (kg) ± SEM		Fat Mass (g) ± SEM		Lean Mass (g) ± SEM		Leptin AM (µg/L) ± SEM		Leptin PM (µg/L) ± SEM		Leptin/Fat × 100
Group	Placebo + DE	ImE	Placebo + DE	ImE	Placebo + DE	ImE	Placebo + DE	ImE	Placebo + DE	ImE	Placebo + DE	ImE
n	12	7–8	14	7–8	14	7–-8	12	6–7	12	6–7	12	6–7
Month
0	7.73 ± 0.36	7.57 ± 0.58	1300 ± 138	1276 ± 275	5925 ± 168	5574 ± 200	6.72 ± 0.87	9.56 ± 0.65	9.52 ± 1.55	9.18 ± 1.11	0.47 ± 0.05	0.47 ± 0.09
6	8.61 ± 0.41	7.67 ± 0.59	2686 ± 319	1840 ± 383	5721 ± 187	5374 ± 194	11.40 ± 0.90	8.90 ± 1.84	11.25 ± 1.04	10.60 ± 2.50	0.50 ± 0.08	0.47 ± 0.16
12	8.71 ± 0.36	8.11 ± 0.66	3087 ± 266	2776 ± 490	5365 ± 165	5025 ± 148	10.62 ± 1.07	8.11 ± 1.27	12.95 ± 1.18	10.71 ± 0.95	0.39 ± 0.04	0.48 ± 0.08
18	9.15 ± 0.40	8.63 ± 0.69	3871 ± 297	3707 ± 548	5042 ± 148	4664 ± 212	13.44 ± 1.37	11.29 ± 1.25	12.96 ± 1.06	10.94 ± 0.88	0.32 ± 0.03	0.21 ± 0.05
24	9.02 ± 0.30	8.79 ± 0.70	3846 ± 290	3621 ± 466	4863 ± 125	4706 ± 187	13.55 ± 1.41	11.08 ± 1.38	14.73 ± 1.25	11.64 ± 1.01	0.36 ± 0.03	0.36 ± 0.03
2-way ANOVA
Interaction	P = 0.96		P = 0.77		P = 0.97		P = 0.29		P = 0.86		P = 0.71
Time	P = 0.005		P < 0.0001		P < 0.0001		P < 0.0001		P < 0.0001		P = 0.025
Treatment	P = 0.032		P = 0.15		P = 0.008		P = 0.027		P = 0.0518		P = 0.74

	Placebo	DE	ImE	Placebo	DE	ImE	Placebo	DE	ImE	Placebo	DE	ImE	Placebo	DE	ImE	Placebo	DE	ImE
n	6	6	7	6	7	7	6	7	7	5	6	6	5	6	6	5	6	6
Month
30	10.05 ± 0.27	8.34 ± 0.50	8.61 ± 0.79	4218 ± 450	3159 ± 326	3888 ± 534	5257 ± 195	4921 ± 277	4735 ± 199	12.89 ± 0.93	9.07 ± 0.94	12.28 ± 0.67	15.76 ± 1.55	9.95 ± 1.35	12.93 ± 0.54	0.38 ± 0.02	0.42 ± 0.03	0.39 ± 0.08
One-way ANOVA	P = 0.134			P = 0.2592			P = 0.31			P = 0.014			P = 0.015			P = 0.49

Placebo + DE represents the combined groups through 24 months, while both were implanted with empty Silastic capsules.