Table 1.
All known human ABC transporters
| Family | Name | ENSEMBL gene | UniProt | Length | Function | 3D structure in use in this study |
|---|---|---|---|---|---|---|
| ABCA | ABCA1 | ENSG00000165029 | Q9UN09 | 2261 | sulfonylurea-sensitive anion transporter | 5xjy (apo form[human ABCA1])[35] |
| ABCA2 | ENSG00000107331 | Q9BZC7 | 2435 | putative transporter | ||
| ABCA3 | ENSG00000167972 | Q99758 | 1704 | putative cholesterol transporter | ||
| ABCA4 | ENSG00000198691 | P78363 | 2273 | inward-directed retinoid flipase in the visual cycle | ||
| ABCA5 | ENSG00000154265 | Q8WWZ7 | 1642 | autolysosome | ||
| ABCA6 | ENSG00000154262 | Q8N139 | 1617 | macrophage lipid homeostasis | ||
| ABCA7 | ENSG00000064687 | Q8IZY2 | 2146 | mcrophage phagocytosis | ||
| ABCA8 | ENSG00000141338 | O94911 | 1581 | lipophilic drug transporter | ||
| ABCA9 | ENSG00000154258 | Q8IUA7 | 1624 | monocyte differentiation | ||
| ABCA10 | ENSG00000154263 | Q8WWZ4 | 1543 | macrophage lipid homeostasis | ||
| ABCA12 | ENSG00000144452 | Q86UK0 | 2595 | lipid homeostasis | ||
| ABCA13 | ENSG00000179869 | Q8N248 | 5058 | lipid homeostasis | ||
|
| ||||||
| ABCB | ABCB1 | ENSG00000085563 | P08183 | 1280 | efflux pump in multidrug-resistant cells | 5ko2 (apo form[mouse ABCB4])[36] 4xwk (inhibitor bound[mouse ABCB4])[37] 5och (ADP bound[human ABCB8]) 6c0v (ATP bound[human ABCB1])[38] |
| TAP1 | ENSG00000168394 | Q03518 | 808 | (heterodimer with TAP2) antigens transporter to ER | ||
| TAP2 | ENSG00000204267 | Q03519 | 686 | (heterodimer with TAP1) antigens transporter to ER | ||
| ABCB4 | ENSG00000005471 | P21439 | 1286 | phospholipid efflux translocator. function as floppase | ||
| ABCB5 | ENSG00000004846 | Q2M3I5 | 1257 | drug efflux transporter | ||
| ABCB6 | ENSG00000115657 | Q9NP58 | 842 | (homodimer) heme and porphyrin uptake to mitochondrion | ||
| ABCB7 | ENSG00000131269 | O75027 | 752 | (homodimer) heme transport from mitochondrion to cytosol | ||
| ABCB8 | ENSG00000197150 | Q9NUT2 | 735 | (homodimer) multidrug resistance exporter at mitochondrion | ||
| ABCB9 | ENSG00000150967 | Q9NP78 | 766 | (homodimer) low-affinity peptide transporter | ||
| ABCB10 | ENSG00000135776 | Q9NRK6 | 738 | (homodimer) mitochondrial transport for heme biosynthesis | ||
| ABCB11 | ENSG00000073734 | O95342 | 1321 | secretion of bile salts | ||
|
| ||||||
| ABCC | ABCC1 | ENSG00000103222 | Q9UQ99 | 1531 | export of organic anions and drugs from the cytoplasm | 5wua (apo form[hamster ABCC8])[26] 5ywc (ADP bound[hamster ABCC8])[39] 5w81 (ATP bound[zebrafish CFTR])[40] |
| ABCC2 | ENSG00000023839 | Q92887 | 1545 | hepatobiliary excretion of numerous organic anions | ||
| ABCC3 | ENSG00000108846 | O95290 | 1527 | transporter in the intestinal excretion of anions | ||
| ABCC4 | ENSG00000125257 | O15439 | 1325 | organic anion pump | ||
| ABCC5 | ENSG00000114770 | Q9UNP5 | 1437 | multispecific organic anion pump | ||
| ABCC6 | ENSG00000091262 | O95255 | 1503 | transport of drugs into subcellular organelles | ||
| CFTR | ENSG00000001626 | P13569 | 1480 | epithelial ion channel | ||
| ABCC8 | ENSG00000006071 | Q09428 | 1581 | subunit of ATP-sensitive potassium channel | ||
| ABCC9 | ENSG00000069431 | O60706 | 1549 | subunit of ATP-sensitive potassium channel | ||
| ABCC10 | ENSG00000124574 | Q5T3U5 | 1492 | lipophilic anion extrusion | ||
| ABCC11 | ENSG00000121270 | Q96J66 | 1382 | enhance the cellular extrusion of cAMP and cGMP | ||
| ABCC12 | ENSG00000140798 | Q96J65 | 1359 | putative transporter | ||
|
| ||||||
| ABCD | ABCD1 | ENSG00000101986 | P33897 | 745 | putative transporter | |
| ABCD2 | ENSG00000173208 | Q9UBJ2 | 740 | putative transporter | ||
| ABCD3 | ENSG00000117528 | P28288 | 659 | branched-chain fatty acid transporter | ||
| ABCD4 | ENSG00000119688 | O14678 | 606 | intracellular processing of vitamin D | ||
|
| ||||||
| ABCE | ABCE1 | ENSG00000164163 | P61221 | 599 | RNase L inhibitor (no TMD) | |
|
| ||||||
| ABCF | ABCF1 | ENSG00000204574 | Q8NE71 | 845 | mRNA translation initiation (no TMD) | |
| ABCF2 | ENSG00000033050 | Q9UG63 | 623 | unknown (no TMD) | ||
| ABCF3 | ENSG00000161204 | Q9NUQ8 | 709 | antiviral effect against flaviviruses (no TMD) | ||
|
| ||||||
| ABCG | ABCG1 | ENSG00000160179 | Q9BXL1 | 678 | macrophage lipid homeostasis | 5do7 (apo form[human ABCG5/ABCG8])[27] 6hbu (ATP bound[human ABCG2])[41] |
| ABCG2 | ENSG00000118777 | Q86V64 | 655 | High-capacity urate exporter | ||
| ABCG4 | ENSG00000172350 | Q9H172 | 646 | macrophage lipid homeostasis | ||
| ABCG5 | ENSG00000138075 | Q9H222 | 651 | sterol transporter | ||
| ABCG8 | ENSG00000143921 | Q9H221 | 673 | sterol transporter | ||