Table 4.
Exploratory Voxelwise Cluster Analyses Outside of a Priori ROIs
| Primary Gray Matter Anatomic Area of Z Maximuma | Hemi-sphereb | MNI Coordinatesc |
Brodmann Aread | Cluster Size (No. Voxels) | Z Maxe | P | Other Anatomic Areas in Clusterf | ||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | |||||||
| Premeal: high-calorie foods > objects | |||||||||
| HW > OB | |||||||||
| OFC | R | 41 | 22 | −17 | 47 | 4798 | 4.17 | 0.0003 | Temporal pole, insular cortex, frontal pole, inferior frontal gyrus, frontal operculum cortex |
| Adjacent to insular ROI | |||||||||
| Temporal fusiform cortex | L | −27 | −35 | −24 | 37 | 4758 | 3.52 | 0.0003 | Parahippocampal gyrus, temporal occipital fusiform cortex, cerebellum, brainstem (pons; middle cerebellar peduncle) |
| Parietal operculum cortex | R | 54 | −33 | 27 | 40 | 4365 | 3.60 | 0.0006 | Planum temporale, supramarginal gyrus, angular gyrus, postcentral gyrus |
| Frontal pole | R | 23 | 63 | 13 | 10 | 3185 | 3.50 | 0.006 | — |
| OFCg (bilateral to above) | L | −27 | 11 | −14 | n/a | 2463 | 3.79 | 0.03 | Insular cortex, temporal pole, planum polare |
| Adjacent to insular ROI | |||||||||
| Superior temporal gyrus | R | 56 | −5 | −13 | 22 | 2444 | 3.62 | 0.03 | Middle temporal gyrus, planum polare |
| OB > HW | |||||||||
| No significant clusters | |||||||||
| Premeal: low-calorie foods > objects | |||||||||
| HW > OB | |||||||||
| No significant clusters | |||||||||
| OB > HW No significant clusters | |||||||||
| Postmeal: high-calorie foods > objects | |||||||||
| HW > OB | |||||||||
| No significant clusters | |||||||||
| OB > HW | |||||||||
| Subcallosal cortex | L | −10 | 21 | −14 | 11 | 5124 | 3.85 | 0.0002 | Frontal orbital cortex, frontal pole (left and right), frontal medial cortex (left and right), frontal orbital cortex (right), subcallosal cortex (right) Adjacent to mOFC and ventral striatial ROIs |
| Occipital pole | L | −12 | −95 | 14 | 18 | 4489 | 3.43 | 0.0006 | Lateral occipital cortex, cuneal cortex |
| Angular gyrus | L | −44 | −51 | 55 | 40 | 4201 | 3.77 | 0.001 | Supramarginal gyrus, postcentral gyrus, lateral occipital cortex, superior parietal lobule |
| Lateral occipital cortex | L | −48 | −73 | 0 | 19 | 3783 | 3.69 | 0.002 | — |
| Occipital poleg (bilateral to above) | R | 16 | −99 | 9 | 18 | 2705 | 3.63 | 0.02 | Lateral occipital cortex, cuneal cortex |
| Middle temporal gyrus | R | 64 | −54 | −1 | 37 | 2613 | 3.48 | 0.02 | Inferior temporal gyrus, lateral occipital cortex |
| Postmeal: low-calorie foods > objects | |||||||||
| HW > OB | |||||||||
| Supramarginal gyrus | R | 68 | −41 | 12 | 22 | 2182 | 3.34 | <0.05 | Middle temporal gyrus, angular gyrus, superior temporal gyrus, planum temporale |
| OB > HW | |||||||||
| No significant clusters | |||||||||
Exploratory analyses excluded previously tested regions of interest (VS, amygdala, DS, insula, VTA/SN, and mOFC). Clusters abutting these regions are indicated in italics. Analyses were corrected for multiple comparisons with a cluster-threshold correction with an individual voxel threshold at Z = 2.3 and a corrected cluster significant threshold of P = 0.05.
Harvard–Oxford Atlas identified regions of local maximum.
Hemisphere of local maximum (L, left; R, right).
Montreal Neurologic Institute coordinates of peak location.
Brodmann area of local maximum (when local maximum was near, but just outside of a Brodmann area, the closest adjacent area was listed).
Maximum Z score.
Other areas identified within the cluster (areas listed are ipsilateral to primary area unless otherwise indicated).
When the local maximum appeared in white matter, the closest gray matter structure within the cluster was listed.