Table 4.
Vemurafenib-Related Adverse Events, All Grades
| Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 | Total |
|---|---|---|---|---|---|---|
| Maculopapular rash | 5 | 2 | 2 | 9 | ||
| Fatigue | 8 | 8 | ||||
| Palmar-plantar erythrodysesthesia syndrome | 3 | 3 | 1 | 7 | ||
| Nausea | 6 | 6 | ||||
| Alkaline phosphatase increased | 5 | 5 | ||||
| Arthralgia | 5 | 5 | ||||
| Bilirubin increased | 4 | 1 | 5 | |||
| Alanine aminotransferase increased | 3 | 3 | ||||
| Diarrhea | 3 | 3 | ||||
| Neoplasm, benign (warts) | 1 | 2 | 3 | |||
| Alopecia | 3 | 3 | ||||
| Skin and subcutaneous tissue disordersa | 2 | 2 | ||||
| Creatinine increased | 2 | 2 | ||||
| Aspartate aminotransferase increased | 2 | 2 | ||||
| Myalgia | 2 | 2 | ||||
| Dysgeusia | 2 | 2 | ||||
| Pruritus | 1 | 1 | 2 | |||
| Anemia | 1 | 1 | ||||
| Constipation | 1 | 1 | ||||
| Cough | 1 | 1 | ||||
| Dry skin | 1 | 1 | ||||
| Hypocalcemia | 1 | 1 | ||||
| Hypophosphatemia | 1 | 1 | ||||
| Dehydration | 1 | 1 | ||||
| Dry mouth | 1 | 1 | ||||
| Eye disorders (other, specify) | 1 | 1 | ||||
| Headache | 1 | 1 | ||||
| Hoarseness | 1 | 1 | ||||
| Mucositis oral | 1 | 1 | ||||
| Oral pain | 1 | 1 | ||||
| Pain | 1 | 1 | ||||
| Skin hyperpigmentation | 1 | 1 | ||||
| Chest wall pain | 1 | 1 |
a
Seborrheic keratosis (1 case), keratosis pilaris-like reaction (1 case).