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. 2019 Apr 1;189:793–803. doi: 10.1016/j.neuroimage.2019.02.007

Table 2.

Overview of the quantitative microstructural indices and their interpretation in white matter.

MRI modality Index Apparent white matter property Hypothesised changes in central obesity
Diffusion NODDI ICSF Axon density Reduction
ODI Axon dispersion Increase
ISOSF Free water Increase
qMT MPF Myelin Neuroinflammation Reduction
kf Neuroinflammation Mitochondrial metabolism Increase in acute inflammation (Harrison et al., 2015);
Reduction in low-level inflammation (Johnson et al., 2012)

Abbreviations: ICSF = intracellular signal fraction, ISOSF = isotropic signal fraction, kf = forward exchange rate, MPF = macromolecular proton fraction, NODDI = neurite orientation dispersion and density imaging, ODI = orientation dispersion index, qMT = quantitative magnetization transfer.