Table 3. Univariate logistic regression models for the prediction of primary endpoint (i.e. the two-year prognosis in terms of all-cause mortality, heart transplantation and/or left ventricular assist device (LVAD) implantation).
| OR (95% CI) | P | ||
|---|---|---|---|
| Anamnesis | |||
| Sex | Men (ref. women) | 1.35 (0.86; 2.13) | 0.197 |
| Age (years) | 10-unit increase | 1.20 (1.04; 1.39) | 0.015 |
| > 70 (ref. ≤ 70) | 1.36 (0.96; 1.93) | 0.083 | |
| BMI | > 30 (ref. ≤ 30) | 0.80 (0.56; 1.14) | 0.218 |
| Diabetes mellitus | Yes (ref. no) | 1.40 (1.00; 1.96) | 0.052 |
| Hypertension | Yes (ref. no) | 1.21 (0.85; 1.74) | 0.296 |
| Smoking | Yes (ref. no) | 1.27 (0.91; 1.77) | 0.164 |
| COPD | Yes (ref. no) | 1.93 (1.26; 2.96) | 0.003 |
| NYHA | III+IV (ref. I+II) | 3.37 (2.39; 4.75) | < 0.001 |
| Heart rate (bpm) | > 90 (ref. ≤ 90) | 1.36 (0.79; 2.34) | 0.267 |
| SBP (mmHg) | < 110 (ref. ≥ 110) | 2.38 (1.53; 3.69) | < 0.001 |
| 10-unit increase | 0.79 (0.71; 0.88) | < 0.001 | |
| DBP (mmHg) | 10-unit increase | 0.63 (0.53; 0.75) | < 0.001 |
| Ejection fraction (%) | < 35 (ref. ≥ 35) | 2.12 (1.44; 3.11) | < 0.001 |
| Atrial fibrillation | Yes (ref. no) | 0.76 (0.44; 1.30) | 0.312 |
| LBBB | Yes (ref. no) | 0.87 (0.59; 1.27) | 0.466 |
| Ischaemic etiology of heart failure | Yes (ref. no) | 1.33 (0.95; 1.86) | 0.095 |
| Duration of heart failure (months) | > 18 (ref. ≤ 18) | 1.26 (0.89; 1.79) | 0.186 |
| Laboratory results | |||
| Hemoglobin (g/l) | < 130 in men, < 120 in women | 2.70 (1.87; 3.89) | < 0.001 |
| NT-proBNP (ng/L) | 126–1,000 (ref. ≤ 125) | 3.74 (1.57; 8.89) | 0.003 |
| > 1,000 (ref. ≤ 125) | 11.34 (4.88; 26.36) | < 0.001 | |
| Cholesterol (mmol/l) | < 3.1 (ref. 3.1–5.8) | 1.37 (0.83; 2.27) | 0.217 |
| > 5.8 (ref. 3.1–5.8) | 0.47 (0.24; 0.93) | 0.030 | |
| Natrium (mmol/l) | < 135 (ref. ≥ 135) | 2.98 (1.77; 4.99) | < 0.001 |
| Uric acid (μmol/l) | > 500 (ref. ≤ 500) | 3.04 (2.09; 4.43) | < 0.001 |
| eGFR (ml/min) | < 60 (ref. ≥ 60) | 1.82 (1.29; 2.56) | < 0.001 |
| Medication | |||
| Furosemide (mg) | Yes (ref. no) | 2.61 (1.50; 4.55) | < 0.001 |
| 1–40 (ref. 0) | 1.22 (0.67; 2.24) | 0.515 | |
| > 40 (ref. 0) | 5.43 (3.06; 9.63) | < 0.001 | |
| Statins | Yes (ref. no) | 1.06 (0.75; 1.50) | 0.753 |
| Betablockers | Yes (ref. no) | 0.50 (0.28; 0.88) | 0.017 |
| ACEI/ARB | Yes (ref. no) | 0.42 (0.27; 0.65) | < 0.001 |
| Spironolacton/eplerenone | Yes (ref. no) | 1.42 (0.97; 2.07) | 0.070 |