Table 3. Significant haplotypes associated with IR in French population and correlation with in vivo insulin sensitivity.
| Haplotype ID (n)a |
Frequency | OR | 95% CI | P-value Regressionb |
Bonferroni correction |
HOMA-IR | 1/ SI | P-valued ANOVA |
|||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lower | Upper | non-carriersc | carriersc | non-carriersc | carriersc | ||||||
| MUT | |||||||||||
| B2_H6 (53)• | 0.08 | 0.13 | 0.02 | 0.99 | 5.91 x 10−3 | NS | 2.57 ± 0.14 | 1.80 ± 0.15 | 0.86 ± 0.15 | 0.30 ± 0.06 | 3.38 x 10−1 |
| B3_H3 (146) | 0.24 | 0.34 | 0.16 | 0.73 | 1.22 x 10−3 | 3.16 x 10−2 | 2.71 ± 0.17 | 1.88 ± 0.14$ | 0.85 ± 0.16 | 0.75 ± 0.27 | 7.73 x 10−1 |
| B3_H12 (51)• | 0.08 | 2.82 | 1.42 | 5.59 | 5.63 x 10−3 | NS | 2.49 ± 0.14 | 2.90 ± 0.52 | 0.75 ± 0.14 | 1.52 ± 0.64 | 1.53 x 10−2* |
| B4_H2 (46)• | 0.07 | 3.07 | 1.53 | 6.17 | 3.00 x 10−3 | 2.40 x 10−2 | 2.46 ± 0.14 | 3.25 ± 0.56 | 0.74 ± 0.13 | 1.59 ± 0.67 | 1.46 x 10−2* |
| B4_H8 (146) | 0.24 | 0.33 | 0.15 | 0.70 | 1.60 x 10−3 | 1.28 x 10−2 | 2.74 ± 0.17 | 1.84 ± 0.13$ | 0.87 ± 0.17 | 0.69 ± 0.25 | 5.83 x 10−1 |
| AACS | |||||||||||
| B17_H1 (177)• | 0.28 | 2.25 | 1.38 | 3.67 | 1.48 x 10−3 | 2.52 x 10−2 | 2.24 ± 0.16 | 2.71 ± 0.26 | 0.62 ± 0.13 | 1.17 ± 0.30 | 9.30 x 10−3* |
| B17_H3 (39) | 0.06 | 0.18 | 0.02 | 1.30 | 2.29 x 10−2 | NS | 2.52 ± 0.13 | 2.66 ± 1.03 | 0.84 ± 0.14 | 0.50 ± 0.13 | 5.96 x 10−1 |
| B18_H6 (94)• | 0.14 | 2.01 | 1.10 | 3.66 | 3.12 x 10−2 | NS | 2.47 ± 0.15 | 2.77 ± 0.35 | 0.78 ± 0.16 | 0.97 ± 0.30 | 6.04 x 10−1 |
| B19_H6 (97)• | 0.15 | 2.42 | 1.38 | 4.26 | 3.23 x 10−3 | 1.61 x 10−2 | 2.49 ± 0.15 | 2.70 ± 0.33 | 0.88 ± 0.17 | 0.59 ± 0.15 | 3.54 x 10−2* |
| B19_H17 (76) | 0.12 | 0.36 | 0.13 | 1.05 | 2.50 x 10−2 | NS | 2.52 ± 0.14 | 2.57 ± 0.66 | 0.85 ± 0.15 | 0.46 ± 0.15 | 4.68 x 10−1 |
| SLC6A15 | |||||||||||
| B1_H1 (286) | 0.46 | 1.66 | 1.02 | 2.70 | 3.08 x 10−2 | NS | 2.42 ± 0.18 | 2.66 ± 0.21 | 0.65 ± 0.15 | 1.01 ± 0.24 | 2.03 x10-1 |
| B2_H1 (256) | 0.41 | 1.73 | 1.07 | 2.81 | 2.25 x 10−2 | NS | 2.36 ± 0.17 | 2.77 ± 0.24 | 0.63 ± 0.14 | 1.11 ± 0.27 | 9.45 x 10−2 |
| B3_H5 (70)• | 0.11 | 0.41 | 0.14 | 1.15 | 4.24 x 10−2 | NS | 2.52 ± 0.14 | 2.58 ± 0.51 | 0.85 ± 0.15 | 0.62 ± 0.26 | 6.17 x 10−1 |
| PRKCA | |||||||||||
| B65_H18 (28) | 0.04 | 4.43 | 1.96 | 10.0 | 1.19 x 10−3 | 2.00 x 10−2 | 2.46 ± 0.14 | 3.44 ± 0.70 | 0.74 ± 0.13 | 1.79 ± 0.99 | 1.00 x 10−4* |
| B66_H4 (43) | 0.06 | 2.76 | 1.32 | 5.76 | 1.00 x 10−2 | NS | 2.48 ± 0.14 | 3.05 ± 0.57 | 0.70 ± 0.12 | 1.97 ± 0.88 | 1.00 x 10−4* |
| B92_H1 (258) | 0.41 | 1.68 | 1.04 | 2.74 | 4.24 x 10−2 | NS | 2.38 ± 0.16 | 2.76 ± 0.25 | 0.76 ± 0.18 | 0.92 ± 0.21 | 5.97 x 10−1 |
| B92_H6 (41) | 0.06 | 0.16 | 0.02 | 1.21 | 1.69 x 10−2 | NS | 2.58 ± 0.14 | 1.73 ± 0.16 | 0.86 ± 0.15 | 0.34 ± 0.06 | 3.27 x 10−1 |
| B93_H6 (36) | 0.06 | 0.18 | 0.02 | 1.29 | 2.52 x 10−2 | NS | 2.57 ± 0.14 | 1.77 ± 0.18 | 0.85 ± 0.15 | 0.34 ± 0.07 | 3.77 x 10−1 |
Association of haplotypes in genomic regions performed in French population and correlated with HOMAIR and 1/SI values from minimal model calculation after IVGTT.
an is expressed at 2n chromosomes
b,d Statistical significance in logistic regression and ANOVA, respectively
c Values are expressed as mean ± SEM
*Values adjusted for hyperglycemia
•, Significance only in French population
$ P < 5 x10-2, OR, odds ratio; 95% CI, confidence interval; HOMAIR, homeostasis model assessment of insulin resistance; SI, insulin sensitivity; NS, non-significant