| Associated co-morbidities |
What are the outcomes in children with multiple co-morbidities? |
| What are the common co-morbidities in children with a single ventricle heart condition? |
| What is the impact of syndromes or other co-morbidities on the quality of life of those with a single ventricle heart condition and their families? |
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| Brain & neurodevelopment |
What factors influence neurodevelopmental outcomes in children with single ventricle heart conditions? |
| Are there differences in brain development in the fetus with a single ventricle heart condition and if so, what is the impact on outcomes? |
| What is the impact of a single ventricle heart condition on neurodevelopment? |
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| Exercise |
What are the effects of regular physical exercise on well-being and long-term outcome in the Fontan circulation? |
| What type of exercise is most beneficial in those with a Fontan circulation? |
| What are the benefits of exercise rehabilitation in well and deteriorating patients with a Fontan circulation? |
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| Fontan failure |
What are the best markers of deterioration in patients with a Fontan circulation? |
| What is the main mechanism behind failure of the Fontan circulation? |
| How can we prevent late multi-organ dysfunction in the Fontan circulation? |
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| Heart function |
What is the cause of ventricular dysfunction in the single ventricle? |
| How can ventricular function be best preserved in patients with a single ventricle heart condition? |
| What treatments can be developed for ventricular failure in patients with a Fontan circulation? |
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| Living with a single ventricle heart condition |
What are the frequencies of symptoms, limitations, physical and emotional quality of life with a Fontan circulation? |
| What lifestyle choices (eg. diet, exercise, occupation, physical location) best support the long-term health of patients with a single ventricle heart condition? |
| What are the long-term social, psychosocial and other non-clinical outcomes of children with single ventricle heart conditions? |
| Which models of care, virtual ward and home monitoring programmes, best support infants, children and young people with a single ventricle heart condition at home? |
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| Management of the well-functioning Fontan circulation |
How can the longevity of the Fontan circulation be prolonged? |
| How can organ function be optimised in patients with a Fontan circulation? |
| What factors best determine a well-functioning Fontan circulation? |
| What is the optimal interval for follow-up of patients with a Fontan circulation? |
| What is the impact of pregnancy on patients with a Fontan circulation and how can outcomes be improved? |
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| Surgery & perioperative care |
Which modifiable perioperative factors can reduce mortality for the Norwood operation? |
| How can perinatal risk stratification be used to identify those in whom the Norwood operation is futile? |
| How could technology be used to perform a biventricular repair in patients with a single ventricle heart condition? |
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| Transplantation, mechanical support & novel therapies |
How can mechanical assist devices be developed to support the Fontan circulation? |
| What are the roles of novel therapies in the failing Fontan? |
| What are the alternatives to transplantation for the failing Fontan? |
