. 2018 Nov 23;104(5):1449–1458. doi: 10.1210/jc.2018-02143

Table 3.

Comparison of Changes in Biochemical Parameters Over 12 Months in the NONE, PILL, and PATCH Groups (Within- and Between-Group Comparisons)

Change Over 12 Months	NONE (n = 26)	P Value^a	PILL (n = 21)	P Value^a	PATCH (n = 26)	P Value^a	ANOVA P Value^b	P Values
Change Over 12 Months	NONE (n = 26)	P Value^a	PILL (n = 21)	P Value^a	PATCH (n = 26)	P Value^a	ANOVA P Value^b	PILL vs NONE	PATCH vs NONE	PATCH vs PILL
Δ 25(OH)D (ng/mL)	1.55 ± 1.60	0.344	2.78 ± 2.21	0.224	−0.17 ± 1.35	0.904	0.482	0.871	0.743	0.458
Δ Calcium (mg/dL)	0.02 ± 0.08	0.842	0.06 ± 0.12	0.624	0.05 ± 0.09	0.611	0.945	0.944	0.970	0.995
Δ PTH (pg/mL)	0.40 ± 2.42	0.870	−0.27 ± 3.09	0.925	1.60 ± 1.94	0.418	0.857	0.979	0.931	0.849
Δ P1NP (ng/mL)	−14.6 (–34.1 to 9.6)	0.049	−26.0 (–64.8 to –18.5)	0.0003	−11.5 (–38.8 to 4.6)	0.031	0.033	0.070	0.978	0.053
Δ NTX (nM BCE/L)	−0.9 (–5.0 to 1.6)	0.035	−1.4 (–4.1 to 1.4)	0.146	−2.0 (–5.0 to 0.7)	0.128	0.907	0.997	0.952	0.907
Δ IGF-1 (ng/mL)	−8.8 ± 15.8	0.584	−65.2 ± 21.2	0.006	−10.2 ± 13.2	0.448	0.037	0.052	0.998	0.066
Δ IGF-1 z score	0.11 ± 0.13	0.414	−0.56 ± 0.22	0.018	0.05 ± 0.16	0.780	0.014	0.018	0.959	0.039
Δ IGFBP-3 (ng/mL)	−236.6 ± 93.8	0.024	252.4 ± 153.7	0.129	−409.5 ± 163.7	0.028	0.006	0.040	0.633	0.006
Δ IGF-1/IGFBP-3	−0.0006 ± 0.0029	0.831	−0.0186 ± 0.0030	<0.0001	0.0015 ± 0.0033	0.6464	0.001	0.003	0.887	0.002
Δ Testosterone (ng/dL)	−1.12 ± 1.79	0.537	−0.68 ± 4.16	0.866	−1.84 ± 2.21	0.414	0.955	0.993	0.980	0.952
Δ Estradiol (pg/mL)	−1.5 (–13.9 to 47.8)	0.079	−20.0 (–89.0 to 0.0)	0.047	45.0 (11.5 to 73.8)	0.0009	<0.0001	0.076	0.014	<0.0001
Δ SHBG (nmol/L)	−5.3 (–14.0 to 12)	0.359	152.4 (99.1 to 232.3)	<0.0001	4.6 (–10.5 to 16.1)	0.814	<0.0001	<0.0001	0.819	<0.0001
Δ FAI	−0.1 (–0.8 to 0.7)	0.613	−1.1 (–2.0 to –0.6)	0.0001	−0.1 (–1.0 to 0.7)	0.313	0.003	0.004	0.990	0.015
Δ Sclerostin (pg/mL)	12.4 ± 16.7	0.467	−45.6 ± 13.8	0.005	−58.2 ± 20.0	0.012	0.010	0.045	0.014	0.863
Δ Pref–1 (pg/mL)	2.0 (–16.4 to 41.5)	0.691	−8.3 (–36.7 to –1.2)	0.055	−33.5 (–64.6 to 5.1)	0.014	0.838	0.943	0.825	0.970
Δ BDNF (ng/mL)	0.31 (–26.54 to 5.66)	0.809	1.03 (–7.97 to 6.13)	0.801	−6.36 (–11.19 to 0.97)	0.044	0.131	0.998	0.113	0.336

Bold type indicates statistically significant P value of <0.05.

Mean ± SEM; median (first quartile to third quartile).

^{^a}

P value for within-group comparison (paired t test or signed rank test).

^{^b}

ANOVA P value for between-group comparisons.