Table 2. Diagnostic accuracy estimates based on different thresholds of pleural fluid adenosine deaminase.
| Adenosine deaminase threshold range | <36 IU/L | 40±4 IU/L | 45–65 IU/L | >65 IU/L | Overall |
|---|---|---|---|---|---|
| Number of studies | 49 | 65 | 56 | 4 | 174 |
| Median prevalence of tuberculosis in studies | 0.39 | 0.46 | 0.41 | 0.44 | 0.41 |
| Summary sensitivity | 0.91 (0.88–0.94) |
0.93 (0.90–0.95) |
0.91 (0.88–0.94) |
0.86 (0.61–0.96) |
0.92 (0.90–0.93) |
| Summary specificity | 0.89 (0.87–0.91) |
0.90 (0.87–0.92) |
0.90 (0.87–0.92) |
0.94 (0.80–0.99) |
0.90 (0.88–0.91) |
| Summary diagnostic odds ratio | 86.32 (56.42–132.08) |
109.51 (71.52–167.67) |
91.57 (55.05–152.33) |
96.55 (14.75–632.17) |
97.42 (74.90–126.72) |
| Positive likelihood ratio* | 8.60 | 8.88 | 8.91 | 14.62 | 8.92 |
| Negative likelihood ratio* | 0.10 | 0.08 | 0.10 | 0.15 | 0.09 |
| Positive predictive value at median prevalence* | 0.85 | 0.88 | 0.86 | 0.92 | 0.86 |
| Negative predictive value at median prevalence* | 0.94 | 0.93 | 0.94 | 0.89 | 0.94 |
| Positive predictive value at 20% prevalence* | 0.68 | 0.69 | 0.69 | 0.79 | 0.69 |
| Negative predictive value at 20% prevalence* | 0.98 | 0.98 | 0.98 | 0.96 | 0.98 |
| Positive predictive value at 60% prevalence* | 0.93 | 0.93 | 0.93 | 0.96 | 0.93 |
| Negative predictive value at 60% prevalence* | 0.87 | 0.89 | 0.87 | 0.81 | 0.88 |
Figures in parentheses are 95% confidence limits
* Values calculated from summary sensitivity and specificity estimates