Table 1.
Characteristics of cases included in this study
| Case # | M/F | Age | CAPS # | Risk group | Study group | Lesion | # of lesions | Largest lesion (mm) | EUS | Diagnosis |
|---|---|---|---|---|---|---|---|---|---|---|
| #104 | F | 84 | CAPS4 | Control | Disease control | Normal pancreas | na | na | Normal pancreas | Suspicion of dilated CBD |
| #108 | M | 46 | CAPS5 | Control | Disease control | Normal pancreas | na | na | Normal pancreas | Suspicion of a pancreatic lesion by CT |
| #109 | F | 54 | CAPS5 | Control | Disease control | Normal pancreas | na | na | Normal pancreas | Abdominal pain |
| #122 | M | 59 | CAPS4 | Control | Disease control | Normal pancreas | na | na | Normal pancreas | Weight loss |
| #123 | F | 47 | CAPS4 | Control | Disease control | Normal pancreas | na | na | Normal pancreas | Duodenal diverticulum, history of acute pancreatitis |
| #131 | F | 56 | CAPS4 | Control | Disease control | Normal pancreas | na | na | Normal pancreas | A lesion adjacent to celiac artery by CT |
| #134 | M | 76 | CAPS4 | Control | Disease control | Normal pancreas | na | na | Normal pancreas | Suspicion of a pancreatic lesion by CT |
| #135 | F | 69 | CAPS4 | Control | Disease control | Normal pancreas | na | na | Normal pancreas | Suspicion of a cystic lesion by EUS 3 years ago |
| #137 | F | 38 | CAPS4 | Control | Disease control | Normal pancreas | na | na | Normal pancreas | CBD stone |
| #089 | F | 74 | CAPS5 | Familial | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #091 | F | 79 | CAPS5 | Familial | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #093 | M | 71 | CAPS5 | Familial | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #095 | M | 78 | CAPS4 | Familial | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #099 | M | 72 | CAPS4 | High risk—BRCA2 | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #121 | M | 67 | CAPS4 | High risk—BRCA2 | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #124 | F | 70 | CAPS5 | Familial | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #105 | M | 70 | CAPS4 | Familial | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #127 | M | 70 | CAPS5 | Familial | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #128 | M | 73 | CAPS4 | High risk—BRCA1 | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #129 | F | 70 | CAPS4 | Familial | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #130 | F | 69 | CAPS5 | Familial | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #132 | F | 67 | CAPS5 | Familial | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #133 | F | 65 | CAPS5 | Familial | Surveillance | No mass, no cyst | na | na | Normal pancreas | CAPS surveillance |
| #090 | M | 77 | CAPS5 | High risk—p16 | Surveillance | Cyst | 1 | 7 | Cyst in tail | IPMN suspected by EUS |
| #092 | M | 74 | CAPS5 | Familial | Surveillance | Cysts | 4 | 18 | Cysts in body and head | IPMN suspected by EUS |
| #096 | M | 71 | CAPS4 | Familial | Surveillance | Cysts | 2 | 5 | Cysts in body and tail | IPMN suspected by EUS |
| #100 | M | 72 | CAPS4 | Familial | Surveillance | Cysts | 3 | 7 | Cysts in body | IPMN suspected by EUS |
| #110 | M | 75 | CAPS5 | Familial | Surveillance | Cysts | 6 | 14 | Cysts in head, body and tail | IPMN suspected by EUS |
| #111 | M | 70 | CAPS5 | Familial | Surveillance | Cysts | 2 | 15 | Cysts in body and head | IPMN suspected by EUS |
| #112 | M | 72 | CAPS4 | Familial | Surveillance | Cysts | 2 | 11 | Cysts in head and body | IPMN suspected by EUS |
| #113 | F | 58 | CAPS4 | Familial | Surveillance | Cysts | 3 | 11 | Cysts in body | IPMN suspected by EUS |
| #114 | M | 63 | CAPS4 | Familial | Surveillance | Cysts | 3 | 16 | Cysts in tail, head and body | IPMN suspected by EUS |
| #115 | M | 62 | CAPS5 | High risk—PJS | Surveillance | Cysts | 3 | 17 | Cysts in head, body and tail | IPMN suspected by EUS |
| #116 | F | 38 | CAPS5 | High risk—PJS | Surveillance | Cysts | 4 | 17 | Cysts in head, tail and body | IPMN suspected by EUS |
| #117 | F | 69 | CAPS5 | Familial | Surveillance | Cysts | 5 | 11 | Cysts in head, tail, body, 5 mm hypoechoic lesion in tail | IPMN suspected by EUS, follow-up a hypoechoic lesion |
| #118 | F | 53 | CAPS5 | High risk—BRCA2 | Surveillance | Cyst | 1 | 12 | Cyst in body | IPMN suspected by EUS |
| #119 | F | 68 | CAPS5 | Familial | Surveillance | Cysts | 7 | 15 | Cysts in head and tail | IPMN suspected by EUS |
| #120 | F | 54 | CAPS5 | Familial | Surveillance | Cyst | 1 | 12 | Cyst in tail | IPMN suspected by EUS |
| #126 | F | 72 | CAPS5 | Familial | Surveillance | Cyst—5 mm | Cyst in uncinate | CAPS surveillance | ||
| #136 | F | 57 | CAPS5 | High risk—PALB2 | Surveillance | Cysts | 13 | 12 | Cysts in head, tail and body | IPMN suspected by EUS |
| #077 | M | 57 | CAPS5 | Incidental | Precursor—LG | Mass | 1 | 34 | Normal pancreas, no evidence of mass | Pathology: chronic pancreatitis, PanIN-2 |
| #072 | F | 58 | CAPS4 | High risk—PRSS1 | Precursor—LG | Cyst | 1 | 12 | Cyst in body, chronic pancreatitis, 6-mm dilated MPD | Pathology: IPMN IGD, chronic pancreatitis, PanIN-2 |
| #075 | M | 64 | CAPS4 | High risk—BRCA2 | Precursor—LG | Solid lesion | 1 | 14 | Hypoechoic lesion in tail | Pathology: Chronic pancreatitis, PanIN-2 |
| #076 | M | 69 | CAPS5 | Familial | Precursor—LG | Cysts | 6 | 6 | Cysts in body and tail, 7-mm dilated MPD | Pathology: IPMN IGD, PanIN-1B |
| #107 | F | 61 | CAPS5 | Incidental | Precursor—LG | MPD dilatation | 1 | 10 | Dilated MPD, 10 mm | Pathology: IPMN IGD, PanIN-2 |
| #087 | M | 65 | CAPS5 | Incidental | Precursor—LG | Cyst | 1 | 34 | Cyst in body, 5-mm dilated MPD | Pathology: IPMN LGD |
| #071 | M | 65 | CAPS4 | Familial | Precursor—LG | Cysts | Many | 28 | Cysts in body, head and tail | Pathology: IPMN IGD, PanIN-2 |
| #070a | M | 62 | CAPS4 | Familial | Precursor—ERCP | Cysts | 2 | 5 | Cysts in head and body, 6-mm dilated MPD | Pathology: incipient IPMN, PanIN-2 |
| #079 | M | 57 | CAPS5 | McCune–Albright syndrome | Precursor—McCune– Albright syndrome | Cysts | Many | 17 | Cysts in head, body and tail, 13-mm dilated MPD | McCune-Albright syndrome, Pathology: IPMN LGD |
| #073 | F | 66 | CAPS4 | Familial | Precursor—HG | Cysts | 12 | 17 | Cysts in body, head and tail | Pathology: multifocal PanIN with focal HGD (PanIN-3) |
| #074 | F | 65 | CAPS4 | High risk—PJS | Precursor—HG | Cysts | 4 | 10 | Cysts in head and body | Pathology: IPMN HGD, PanIN-2 |
| #081 | F | 87 | CAPS5 | Incidental | Precursor—HG | Cyst | 1 | 28 | Cyst with solid component in head | Pathology: IPMN HGD |
| #098 | M | 77 | CAPS4 | Incidental | Precursor—HG | Cysts | 2 | 21 | Cysts in head and body | Pathology: IPMN HGD, PanIN-2 |
| #078 | F | 75 | CAPS5 | PC | PC | Mass | 1 | 40 | Mass in head, 10-mm dilated MPD | Pathology: PDAC, stage IV, diagnosed by FNA |
| #080 | F | 78 | CAPS5 | PC | PC | Mass | 1 | 36 | Mass in head | Pathology: PDAC, ypStage IB |
| #082 | M | 62 | CAPS5 | PC | PC | Mass | 1 | 32 | Mass in head, 4-mm dilated MPD | Pathology: PDAC, stage IV, diagnosed by FNA |
| #083 | F | 72 | CAPS5 | PC | PC | Mass | 1 | 37 | Mass in head, 6-mm dilated MPD | Pathology: PDAC, stage IIB |
| #084 | M | 72 | CAPS5 | PC | PC | Cyst | 1 | 36 | Cyst with 12-mm solid component in head | Pathology: PDAC arising in an IPMN, stage IA, IPMN, PanIN |
| #085 | M | 73 | CAPS5 | PC | PC | Mass | 1 | 49 | Mass in head, 10-mm dilated MPD | Pathology: PDAC, stage IIB, PanIN-2 |
| #086 | M | 65 | CAPS5 | PC | PC | Mass | 1 | 27 | Mass in body, 8-mm dilated MPD | Pathology: PDAC, ypStage IIB |
| #088 | F | 77 | CAPS5 | PC | PC | Mass | 1 | 29 | Mass in head, 6-mm dilated MPD | Pathology: PDAC, locally advanced, diagnosed by FNA |
| #094 | M | 53 | CAPS5 | PC | PC | Mass | 1 | 30 | Mass in body, 5-mm dilated MPD | Pathology: PDAC, locally advanced, diagnosed by FNA |
| #097 | M | 51 | CAPS5 | PC | PC | Mass | 1 | 24 | Mass in head, 6-mm dilated MPD | Pathology: PDAC, ypStage IIB |
| #101 | M | 85 | CAPS4 | PC | PC | Mass, cyst | 2 | 35 | Mass in tail, 4-mm cyst in body, 4-mm dilated MPD | Pathology: colloid carcinoma arising in an IPMN, stage IA, IPMN HGD |
| #102 | M | 68 | CAPS4 | PC | PC | Mass | 1 | 30 | Mass in head, 7-mm dilated MPD | Pathology: PDAC, stage IIB |
| #103 | M | 61 | CAPS4 | PC | PC | Cyst | 1 | 31 | Cyst with solid compornent in body, 7-mm dilated MPD | Pathology: PDAC arising in an IPMN, stage IB, IPMN HGD |
| #106 | F | 62 | CAPS4 | PC | PC | Mass | 1 | 25 | Mass in tail, 5-mm dilated MPD | Pathology: PDAC, stage IIB |
Abbreviations: CBD, common bile duct; CT, computed tomography; ERCP, endoscopic retrograde cholangiopancreatography; F, female; FNA, fine-needle aspiration; HG, high grade; HGD, high-grade dysplasia; IGD, intermediate-grade dysplasia; LG, low grade; LGD, low-grade dysplasia; M, male; MPD, main pancreatic duct; na, not applicable; PC, pancreatic cancer; Precursor, surgical resection for precursors; ypStage, pathologic stage after neoadjuvant therapy.
a
ERCP.