The key nodes in our analysis were triage strategy (drip-and-ship vs. mothership), treatment with IV-tPA, presence of an LVO, treatment with endovascular therapy, and anticipated outcomes for all treatment types. The decision analysis model used time-dependent and time-independent probabilities derived from published estimates and guidelines. Squares are decision nodes representing a decision-making point; circles represent chance nodes followed by subsequent event probabilities. mRS, modified Rankin Scale; LVO, large vessel occlusion; IV-tPA, intravenous tissue plasminogen activator; drip-and-ship, transporting to the closest primary stroke center first; mothership, transporting directly to a comprehensive stroke center.