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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Neuroimage. 2018 Dec 1;188:188–197. doi: 10.1016/j.neuroimage.2018.11.062

Figure 4.

Figure 4.

Cocained-induced ΔCBFv and ΔHbO2 in the awake and isoflurane anesthetized states. a) Images to show CBFv difference between baseline (t=0min) and after cocaine (t=25min) in the awake (a0-a1) and anesthetized states (a2-a3). b1) ΔCBFv rapidly decreased 13.2±13.5% at ~3min post cocaine and remained low in the anesthetized state (orange line) [F(34,102)=5.66, p<0.001], but showed no significant change [F=(34,102)=1.51, p=0.06] in the awake state (green line). b2) Cocaine-induced mean ΔCBFv in the awake and anesthetized states were significantly different (p=0.04). c1) ΔHbO2 rapidly decreased −5.11±1.83% at ~3min post cocaine and remained low [F(34,102)=8.35, p<0.001] in the anesthetized state, but showed no significant change in the awake state [F(34,102)=0.76, P=0.82]. c2) Cocaine-induced mean ΔHbO2 in the awake and anesthetized states were significantly different (p=0.03). d) ΔHbO2 and ΔCBFv showed strong positive correlation with R(899)=0.90 (p<0.001) in the anesthetized state and R(899)=0.61 (p<0.001) in the awake state during t=-5 to 10min.