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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Alzheimers Dement. 2018 Sep 19;15(1):65–75. doi: 10.1016/j.jalz.2018.08.002

Figure 1. Pair-wise polygenic association analyses between GW-ADPRS and (A) cognition scores, (B) vascular pathologies.

Figure 1.

We derived genome-wide PRS for AD dementia using ADGC GWAS as the discovery sample with three different P-value thresholds (PT used to select training set SNPs: 0.0001, 0.001, and 0.01) and apply them to (A) Z-score of the composite memory or global cognition score; and (B) each of the markers of vascular pathologies. Age and sex were included as covariates in the association analyses.

Each pair is shown on the x-axis and the proportion of variance explained for each phenotype (estimated via partial correlation R2) on the y-axis.

Unadjusted P-values are shown on the top of the bars if < 0.05.

An asterisk indicates Bonferroni-corrected P-value < 0.05.