Table 1.
Descriptive statistics of demographic and clinical characteristics
| Characteristics | All subjects (N=5161) |
Subjects with genotype data (N=2907) |
|---|---|---|
| Demoaraphic | ||
| Age at AGES I (years), mean (SD) | 76.73 (5.83) | 76.20 (5.43) |
| Sex | ||
| Female, N (%) | 3022 (58.6) | 1706 (58.7) |
| Education | ||
| Secondary, N (%) | 2406 (49.9) | 1441 (49.7) |
| College, N (%) | 755 (15.7) | 451 (15.6) |
| University, N (%) | 547 (11.4) | 334 (11.5) |
|
Vascular Patholoaies, Baseline Lobar cerebral microbleeds |
||
| Count>=2, N(%) | 110 (2.1) | 69 (2.7) |
| White matter lesion load, median(Q1, Q3) | 1.91 (0.51, 5.64) | 1.92 (0.50, 5.59) |
| Central retinal venular equivalent, mean(SD) | 202.19 (19.56) | 202.14 (19.50) |
| Carotid intima-media thickness, median(Q1,Q3) | 0.97 (0.88, 1.06) | 0.97 (0.88, 1.06) |
| Coronary calcification score, median(Q1, Q3) | 271.23 (43.61, 898.78) | 253.52 (38.94, 841.53) |
|
Other Covariates, Baseline Midlife physical activity |
||
| Intermediate, N(%) | 2166 (46.6) | 1327 (47.5) |
| Poor, N(%) | 909 (19.5) | 524 (18.8) |
| Diet quality | ||
| Intermediate, N(%) | 4011 (84.6) | 2418 (84.8) |
| Poor, N(%) | 354 (7.5) | 205 (7.2) |
| Smoking | ||
| Ever, N(%) | 2111 (43.9) | 1303 (44.8) |
| Current, N(%) | 593 (12.3) | 372 (12.8) |
| Diabetes, N(%) | 640 (12.4) | 324 (11.2) |
| Hypertension | ||
| Prehypertension, N(%) | 758 (14.8) | 445 (15.3) |
| Hypertension, N(%) | 4112 (80.3) | 2318 (79.8) |
| LDL level >=130 mg/dL, N(%) | 2830 (54.9) | 1643 (56.6) |
| BMI>=30, N(%) | 1139 (22.3) | 642 (22.1) |
Subjects with GWAS genotype data available (n=2,907) had lower coronary calcification score than those without genotype data (n=2,254) (Mann-Whitney U test, P=0.01). No significant difference was observed in the distribution of any other characteristic listed in the Table between subjects with and without genotype data available.