Table 3.
Demographic and disease characteristics of each class
| Weak- Overall (n = 20) |
Typical-Overall (n = 149) |
Strong-Memory (n = 23) |
Weak-Visuospatial (n = 47) |
Amnestic (n = 51) |
Strong-Overall (n = 134) |
Overall sample (n = 424) |
|||
|---|---|---|---|---|---|---|---|---|---|
| Demographics | 1 | 2 | 3 | 4 | 5 | 6 | Total | F | Post-hoc |
| Education (years) Age (years) |
11.84(4.17) 67.74 (7.37) |
15.75 (2.89) 62.53 (8.98) |
14.82 (3) 60.41 (8.71) |
14.89 (2.92) 65.13 (8.41) |
14.88 (2.83) 66.92 (7.19) |
16.39 (2.5) 56.72 (9.94) |
15.51 (3) 61.7 (9.68) |
10.08** 14.64** χ2 |
1< all; 4, 5 < 6 2< 5; 6 < 1,2,4, 5 |
| Female White Hispanic Right-handed ≠ APOE e4 carrier |
4 (20%) 15 (75.0%) 2 (10.0%) 17 (85.0) 5(29.4%) |
31 (20.8%) 142 (95.3%) 1 (0.7%) 134 (89.9%) 33 (23.9%) |
17 (73.9%) 21 (91.3%) 1 (4.3%) 20 (87.0%) 7 (30.4%) |
21 (44.7%) 42 (89.4%) 2 (4.3%) 39 (83.0%) 12 (29.3%) |
8 (15.7%) 48 (94.1%) 0 (0.0%) 46 (90.2%) 13 (29.5%) |
64 (47.8%) 126 (94.0%) 3 (2.2%) 119 (88.8%) 25 (20.7%) |
145 (34.2%) 394 (92.9%) 9(2.1%) 375 (88.4%) 95 (24.7%) |
50.81*** 12.41* 10.18^ 5.06 2.73 |
|
| Diagnostic motor symptoms | χ2 | ||||||||
| Effected side ....Left ....Right ....Both Tremor Rigidity Bradykinesia Postural instability |
9 (45.0%) 11 (55.0%) 0 (0.0%) 15 (75.0%) 18 (90.0%) 18 (90.0%) 2 (10.0%) |
56 (37.6%) 88 (59.1%) 5 (3.4%) 113 (75.8%) 116(78.4%) 122 (82.4%) 12 (8.2%) |
6(26.1%) 16 (69.6%) 1 (4.3%) 14 (60.9%) 18 (78.3%) 19 (82.6%) 3 (13.0%) |
24 (51.1%) 22 (46.8%) 1 (2.1%) 42 (89.4%) 36 (76.6%) 37 (78.7%) 0 (0.0%) |
24 (47.1%) 27 (52.9%) 0 (0.0%) 42 (82.4%) 33 (64.7%) 38 (77.6%) 4 (8.0%) |
60 (44.8%) 71 (53.0%) 3 (2.2%) 106 (79.1%) 102 (77.3%) 115 (85.8%) 8 (6.1%) |
179 (42.2%) 235 (55.4%) 10 (2.4%) 332 (78.3%) 323 (76.7%) 349 (82.9%) 29 (6.9%) |
8.30 8.70 6.38 3.11 5.72 |
|
| MDS-UPDRS | |||||||||
| Total score ....Part I ....Part II ....Part III Tremor score PIGD score |
37.16(13.38) 7.05 (4.12) 6.15 (3.39) 24.4(11.60) 0.48 (0.35) 0.32(0.18) |
32.59 (13.39) 5.83 (4.52) 6.02 (4.41) 20.1 (9.21) 0.53 (0.35) 0.24 (0.24) |
35.18 (15.76) 6.83 (4.45) 7.26 (5.30) 21.74 (8.79) 0.46 (0.31) 0.3 (0.24) |
33.47 (13.01) 5.35 (3.48) 6.36 (4.34) 21.74 (8.57) 0.53 (0.30) 0.22 (0.20) |
33.29 (12.77) 6.58 (5.09) 5.96 (4.59) 23.1 (9.49) 0.65 (0.39) 0.21 (0.21) |
29.02 (12.00) 5.17 (3.69) 4.95 (3.69) 18.52 (7.80) 0.44 (0.30) 0.18 (0.16) |
32.02 (13.11) 5.77 (4.24) 5.78 (4.24) 20.44 (8.98) 0.51 (0.34) 0.22 (0.21) |
2.47* 1.66 1.92^ 3.31** 3.13** 3.03* |
6 <5; (6 < 1) 6<5 (6 < 1) |
| Other characteristics | |||||||||
| # Relatives with PD ADL Disease duration (mo.) Hoehn & Yahr |
0.37 (0.83) 90.50 (6.67) 5.05 (5.15) 1.53 (0.51) |
0.35 (0.63) 93.42 (5.52) 6.09 (5.37) 1.59 (0.49) |
0.14 (0.35) 91.52 (7.3) 6.82 (8.17) 1.77 (0.43) |
0.16 (0.42) 93.72 (5.46) 6.47 (6.1) 1.69 (0.47) |
0.41 (0.83) 92.84 (6.19) 7.88 (7.29) 1.69 (0.47) |
0.34 (0.74) 93.28 (6.07) 6.69 (7.26) 1.44(0.53) |
0.32 (0.68) 93.1 (5.94) 6.53 (6.48) 1.57 (0.51) |
1.16 1.33 0.80 3.70** |
6 < 5, (6 <3,4) |
Note.
≠
= reflects subsample (n = 384) with available genotyping.
^
= p < 0.10
*
= p < 0.05
**
= p < 0.01
***
= p < 0.001.
Disease duration refers to the length of time between study enrollment and the time at which the patient met clinical diagnostic criteria for PD. Bolded cells reflect classes with larger than expected proportion of associated characteristic; Italicized cells reflect classes with smaller than expected proportions.
Post-hoc relationships in parenthesis indicator marginal significance (0.05 <p < 0.10).
MDS-UPDRS = Movement Disorders Society Unified Parkinson’s Disease Rating Scale; PIDG = postural instability-gait disturbance; ADL = activities of daily living.