Table 4.
Means and SDs of reported non-motor symptoms and available biomarkers
| Weak- Overall |
Typical- Overall |
Strong- Memory |
Weak-Visuospatial | Amnestic | Strong- Overall |
||||
|---|---|---|---|---|---|---|---|---|---|
| Non-motor | 1 | 2 | 3 | 4 | 5 | 6 | Total sample | F | Post-hoc |
| GDS | 3.50 (2.40) | 2.07 (2.20) | 2.30 (2.44) | 1.98 (1.86) | 3.04 (2.88) | 2.29 (2.64) | 2.33 (2.45) | 2.34* | |
| STAI | 76.95 (20.09) | 65.66 (16.52) | 70.43 (17.23) | 68.95 (16.83) | 68.60 (18.24) | 66.39 (18.13) | 67.39 (17.59) | 1.83 | |
| State | 37.25 (10.77) | 32.40 (9.62) | 34.39 (10.27) | 34.61 (10.40) | 33.62 (10.34) | 32.08 (10.73) | 33.01 (10.26) | 1.35 | |
| Trait | 39.70 (10.63) | 33.26 (7.85) | 36.04 (8.73) | 34.20 (7.50) | 34.90 (8.98) | 34.31 (9.03) | 34.35 (8.60) | 2.28 | 2 < 1 |
| RBD | 5.40 (2.98) | 4.13 (2.66) | 4.61 (3.19) | 4.13 (2.86) | 4.60 (2.92) | 3.62 (2.38) | 4.11 (2.70) | 2.30* | (6 < 1) |
| ESS | 6.35 (3.62) | 5.49 (3.10) | 5.13 (3.51) | 5.60 (4.06) | 6.10(3.87) | 5.99 (3.41) | 5.76 (3.45) | 0.69 | |
| UPSIT | 16.55 (8.08) | 21.81 (8.25) | 23.52 (8.31) | 19.47 (8.74) | 21.73 (7.57) | 24.60 (7.77) | 22.27 (8.29) | 5.64*** | 1,4 < 6; |
| (1 < 2, 3); (2 < 6) |
|||||||||
| SCOPA-AUT | 13.60(10.32) | 9.28 (6.07) | 11.48 (6.12) | 8.60 (5.41) | 11.31 (6.37) | 8.64(5.31) | 9.57 (6.18) | 3.99** | 2, 4, 6 < 1 |
| CSF | |||||||||
| Amyloid-β | 339.47 (105.90) | 366.94 (98.88) | 372.26 (105.59) | 352.46 (95.73) | 376.43 (118.27) | 383.27 (94.46) | 370.72 (100.56) | 1.16 | |
| α-Synuclein | 1635.89 (795.93) | 1835.18 (676.41) | 1694.3 (700.73) | 1712.43 (732.94) | 1874.65 (952.21) | 1938.44 (845.84) | 1842.14 (783.96) | 1.10 | |
| p-Tau | 13.11 (6.37) | 15.23 (10.83) | 17.23 (13.66) | 15.04 (8.77) | 17.1 (9.71) | 15.84 (9.49) | 15.65 (10.05) | 0.65 | |
| Total Tau | 44.58 (17.55) | 44.26 (17.15) | 42.61 (17.98) | 44.43 (18.98) | 47.57 (23.28) | 44.6 (17.35) | 44.72 (18.28) | 0.33 | |
| DaT binding | |||||||||
| Caudate (L) | 1.84 (0.60) | 1.98 (0.63) | 2.09 (0.68) | 1.82 (0.72) | 2.04 (0.53) | 2.07 (0.64) | 2.00 (0.64) | 1.44 | |
| Caudate (R) | 1.95 (0.62) | 1.98 (0.66) | 2.14 (0.64) | 1.82 (0.72) | 1.90 (0.71) | 2.06 (0.65) | 1.98 (0.67) | 1.24 | |
| Putamen (L) | 0.79 (0.42) | 0.87 (0.44) | 0.82 (0.39) | 0.77 (0.48) | 0.90 (0.46) | 0.93 (0.44) | 0.88 (0.45) | 1.06 | |
| Putamen (R) | 0.95 (0.40) | 0.94 (0.46) | 1.05 (0.38) | 0.84 (0.48) | 0.94 (0.51) | 1.01 (0.39) | 0.96 (0.44) | 1.16 | |
Note.
*
= p < 0.05;
**
= p < 0.01;
***
= p < 0.001.
Post-hoc relationships in parenthesis indicator marginal significance (0.05 <p < 0.10).
GDS = Geriatric Depression Scale; STAI = State-Trait Anxiety Inventory; RBD = REM Sleep Behavior Disorder Questionnaire; ESS = Epworth Sleepiness Scale; UPSIT = University of Pennsylvania Smell Identification Test; CSF = cerebrospinal fluid; DaT = dopamine transporter binding.