Figure 3. Summary of mean and 95% confidence interval of k_pl values derived from repeated analysis of noisy synthetic data.

The solid green line shows the $k_{pl}$ value used in the generation of simulation data. The solid blue, red, and yellow lines represent the mean fit values for $k_{pl}$ with the constant excitation angle broadband (CEA-bb), constant signal variable excitation angle (VEA-const), and maximal lactate variable excitation angle (VEA-max) design strategies, respectively. The dashed lines represent the 95% CI of the fit results determined from the standard deviation of 100 repeated fits with fresh Gaussian noise. There is no statistical difference between VEA-max and CEA-bb strategies but both have statistically improved repeatability compared to VEA-const strategy.