Table 2:
Results of adjusted linear regression models for in utero TCDD exposure (log10) and child right hand 2D:4D ratio, overall and stratified by child sex, Seveso Second Generation Study, Seveso, Italy, 1976–2016.
| Overall | Female | Male | |||||
|---|---|---|---|---|---|---|---|
| Exposure (ppt)c | N | Adj.a β (95% CI) | N | Adj.b β (95% CI) | N | Adj.b β (95% CI) | p-int |
| 1976 TCDD | 594 | 0.000 (−0.005, 0.005) | 306 | 0.000 (−0.007, 0.007) | 288 | 0.000 (−0.008, 0.008) | 0.90 |
| Pregnancy TCDD | 594 | −0.002 (−0.008, 0.005) | 306 | 0.000 (−0.009, 0.008) | 288 | −0.003 (−0.011, 0.005) | 0.56 |
| Pregnancy total TEQ | 161 | −0.007 (−0.029, 0.015) | 80 | −0.010 (−0.036, 0.016) | 81 | 0.000 (−0.046, 0.046) | 0.61 |
a
Adjusted for: child sex, child age, maternal smoking during pregnancy.
b
Adjusted for: child age, maternal smoking during pregnancy.
c
Results are for a 10-fold increase in exposure.
Abbreviations: 2D, 2nd digit; 4D, 4th digit; CI, confidence interval; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; TEQ, toxic equivalent.