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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Vascul Pharmacol. 2019 Feb 27;114:1–12. doi: 10.1016/j.vph.2019.02.004

Figure 6. CRISPR editing strategies for natural antisense transcript (NAT) lncRNAs and overlapping lncRNAs.

Figure 6.

(A) Screenshot of the NAT lncRNA, Has2os (os signifies opposite strand). This lncRNA is transcribed in the antisense orientation to the proteincoding gene, Has2. Note the much higher conservation of Has2 versus the Has2os lncRNA. Exons here and below are labeled as Ex1, Ex2, etc. (B) Screenshot of the Flicr lncRNA that overlaps two flanking protein-coding genes. (C) Screenshot of a 5’ overlapping lncRNA (Vax2os) whose exons do not intersect exons of the antisense transcribed protein-coding gene, Vax2. See text for more details.