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. 2018 Oct 4;43(2):109–122. doi: 10.1093/femsre/fuy036

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© FEMS 2018.

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Figure 5. — Interaction of DNA PT modifications with other defensive systems. (A) Dnd modification enzymes and Dam can share the same DNA motif, 5΄-GATC-3΄/5΄-GATC-3΄, to generate a hybrid 5΄-G_PS^6mATC-3΄/5΄-G_PS^6mATC-3΄ product modified with a PT in the DNA backbone and methylation of a nucleobase. (B) The methylated species 5΄-G^6mATC-3΄/5΄-G^6mATC-3΄ can be substituted with the PT-modified 5΄-G_PSATC-3΄/5΄-G_PSATC-3΄ to resist cleavage by DndFGH. (C) Bacteria have evolved the type IV ScoMcrA endonuclease to specifically recognise foreign DNA possessing ^5mC and PT.