Figure 11. Statistical distribution of binding energies at binding points of thiamine and its derivatives to the pyruvate decarboxylase.

(a) binding of anti-coenzymes in the case of thiamine diphosphate already bound with active center, (b) binding of thiamine diphosphate in the case of anti-coenzyme already bound; 3-DAT, 3-deazathiamine; A, amprolium; OT, oxythiamine; PT, pyrithiamine; –PP, diphosphate esters of above mentioned compounds; Th, thiamine.